Indianapolis Colts vs. Pittsburgh Steelers, Odds, Preview, Picks and Prediction, Sunday, November 2, 2025
Use Code SSWC First place AFC teams meet up on Sunday afternoon, and you can make sure you are ready for all of the action by checking out our Colts vs. Steelers predictions. Indianapolis (7-1 SU, 6-2 ATS) was a 38-14 winner over Tennessee last weekend as -14.5 favorites at home. Pittsburgh (4-3 SU, 3-4 ATS) was held back by Green Bay, 35-25, as +2.5 favorites at home last week. This matchup kicks off from Heinz Field at 1:00 EST, and for more of the day’s action, check out all of our Free NFL Picks.
Colts in full stride
The Colts are in the midst of a four-game winning streak and are the owners of the best record in football. Last weekend versus Tennessee, the offense found the end zone in all four quarters, while the defense limited the Titans' scoring options by shutting down the run.
The Indy offense has scored over 30 points in four straight games, and they lead the NFL with an average of 33.8 points per game. They also lead the league with 385.3 total yards each week. The passing game is producing 250.9 yards per week behind Daniel Jones, who is fourth in the NFL with 2,062 passing yards. The Colts’ QB has 13 TD strikes, 3 interceptions, and he’s been sacked 9 times. His top target has been Michael Pittman, who has caught 43 of the 56 passes thrown his way for 446 yards and 6 TDs. Tight end Tyler Warren has 37 catches for 492 yards and 3 TDs. The rushing attack is gaining 134.4 yards per game. Jonathan Taylor is the league leader with 850 rushing yards and 12 TDs.
The Colts’ scoring defense is giving up 19.3 points per game, sixth in the NFL, and 345.1 total yards per game, 24th overall. They’ve done fine against the run, allowing just 93.1 yards per game, but struggle versus the pass, giving up 252 yards each time out. They’ve been able to make up for it by recording 23 sacks and 10 interceptions. Three different players have two picks. DeForest Buckner leads the team with 4 sacks as part of his 38 tackles. Nick Cross has a team-high 56 tackles with 1.5 sacks and an interception.
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Injury report (with most recent practice participation status)
- S Nick Cross (shoulder) full
- WR Josh Downs (hip) full
- DE Samson Ebukam (knee) DNP
- G Matt Goncalves (NIR) full
- WR Anthony Gould (knee) DNP
- CB Jaylon Jones (hamstring) full
- DE Tyquan Lewis (groin) full
- CB Kenny Moore II (Achilles) full
- T Braden Smith (NIR) full
- DT Grover Stewart (foot) DNP
Steelers looking for the bounce back
The Steelers were on the right track at 4-1 SU but they’ve lost back-to-back tilts, though they still maintain a firm hold over a soft AFC North. The defense collapsed against Green Bay, allowing 21 points in the fourth quarter as the team got outscored 28-9 in the second half.
The Pittsburgh offense has managed to put up at least 23 points over its last four games, and their 25 points per game ranks 13th in the league. They’ve been able to accumulate 297.1 total yards per game behind a passing game producing 202.9 yards each week. The ageless Aaron Rodgers sits 22nd in the league with 1,489 passing yards. The 41-year-old signal caller has 16 TDs, 5 INTs and has been sacked 12 times. He’s been throwing to DK Metcalf more than anyone else, and the receiver caught 27 of 43 passes thrown his way for 461 yards and 5 TDs. The Steelers’ run game is gaining only 93.1 yards per game. Jaylen Warren has a team-high 373 yards on 83 carries but has yet to find the end zone.
On defense, Pittsburgh is allowing 25 points per game. They are giving up a total of 386 yards each week, the third most yardage allowed in the league. Against the pass, they are yielding 273.3 yards and versus the run, 112.7 yards per game. They have recorded 22 sacks and picked off five interceptions. Payton Wilson leads the team with 57 tackles and has a sack to his credit. Nick Herbig has a team-high 4.5 sacks and T.J. Watt is right behind him with 4.
Injury report (with most recent practice participation status)
- WR Scott Miller (finger) DNP
- WR Ben Skowronek (neck) full
- QB Will Howard (hand) full
- S DeShon Elliott (knee) DNP
- CB Cory Trice Jr. (hamstring) limited
- LB Malik Harrison (knee) full
- C Zach Frazier (calf) limited
- G Isaac Seumalo (pectoral) DNP
- TE Jonnu Smith (NIR) full
- TE Pat Freiermuth (quad) full
- DT Daniel Ekuale (knee) DNP
- WR DK Metcalf (NIR)
- S Kyle Duggar (knee) full
- S Jabrill Peppers (quad) limited
- LB Cole Holcomb (illness) DNP
- DT Cameron Heyward (NIR) DNP
- CB Darius Slay (NIR) DNP
Colts vs. Steelers Picks
Spread Pick for Colts vs. Steelers
- Indianapolis -3 (4 units)
These two teams met last season in a game where the Colts won by three points at home. Indianapolis keeps answering the critics at every turn this season, but now has a bigger target on their back. This will be just their fourth game on the road this season, and they are 2-1 SU away from home. Two of the Steelers’ three losses this season have come in Pittsburgh. Rodgers is starting to come of age, with his completion percentage sinking each week and the sacks ticking up a notch. Indianapolis does not have a strong passing defense in terms of yardage yielded, but they will put the pressure on and make you make mistakes. Colts’ defensive backs are salivating at the chances that lie ahead in this matchup. Indianapolis is 2-0 SU and ATS in the last two meetings.
Take the Colts.
Over/Under Pick for Colts vs. Steelers
- Over 50.5 (5 units)
This matchup features two top-half scoring offenses, including the top-scoring team in the league. The Colts have been held back exactly once this season, and even then, they scored 20 points. In all of their other games, they scored at least 29, and over their last four games, they scored 38 points or more four times. Even in the face of losses, Pittsburgh is still contributing to the cause, averaging 28 points per game in their last two. They have scored 24 points or more in four games this season. Between the two teams, the over is 10-5 this seaso,n and in their last ten meetings, the over is 8-2.
Take the over.
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