Indianapolis Colts vs Pittsburgh Steelers Picks and Prediction for Sunday October 11, 2026
The Indianapolis Colts will travel to Pittsburgh, Pennsylvania, Sunday afternoon for an AFC matchup against the Pittsburgh Steelers at Acrisure Stadium. Kickoff is scheduled for 1 PM with national television coverage on CBS. Indianapolis enters the weekend with a 2-2 record following a convincing 30-13 victory over the Washington Commanders. The Colts will look to build on that performance and move above .500 with another important conference victory. Pittsburgh comes into the game with a 2-2 record after suffering a narrow 27-24 loss to the Cleveland Browns. The Steelers will look to bounce back in front of their home crowd and pick up their third win of the season. Pittsburgh is listed as a 3-point favorite, with the total set at 43.5 points. The Steelers are -148 on the money line, while Indianapolis comes in at +124. Stay in the news with our NFL Picks.
Colts try for 3 in a row
Daniel Jones is leading the Indianapolis offense this season with 754 yards and three touchdowns on 84 completions. Jonathan Taylor is the top ball carrier with 353 yards and two scores on 86 carries. Josh Downs leads the team with 202 yards on 17 receptions. Tyler Warren has added 23 catches for 130 yards and two scores this season. Keenan Allen has chipped in 13 catches for 100 yards and one touchdown.
Indianapolis was a far better team a week ago, compiling 257 yards to score 30 points in the game. Defensively, Indianapolis held their own, giving up 13 points on 317 total yards and forcing 1 turnover in the win. Daniel Jones led the way for the Indianapolis offense last week, completing 19 passes for 143 yards. Jonathan Taylor led the team with 95 yards and two touchdowns on 20 carries. Laquon Treadwell Chipped in heavily with 42 yards on five catches to lead the team. Tyler Warren added five catches for 41 yards in the game.
Key Injury Report for Indianapolis:
- Ashton Dulin (Out) – Hamstring
- Tanor Bortolini (Questionable) – Ankle
- Keenan Allen (Questionable) – Groin
- Charvarius Ward (Questionable) – Groin
- Will Mallory (IR-R) - Thumb
Steelers hunt the home win
Aaron Rodgers is leading the Pittsburgh offense this season with 999 yards and seven scores on 88 completions. Jaylen Warren is the top running back on the team with 309 yards on 55 carries. DK Metcalf leads the team with 213 yards and one touchdown on 16 receptions. Roman Wilson has chipped in 14 catches for 188 yards and two scores.
The Pittsburgh Steelers offense did move the ball well last week, scoring 24 points, including fourteen in the fourth quarter on 361 total yards, but turned the ball over 2 times and converted just 4 third downs. Defensively, Pittsburgh was outmatched, giving up 27 points on just over 370 yards. Aaron Rodgers led the show for the Pittsburgh offense last week with 299 yards and three scores on 22 completions. Jaylen Warren led the way on the ground for Pittsburgh with 93 yards on 17 carries. DK Metcalf led the team with 115 yards on five receptions. Roman Wilson chipped in at 74 yards and one score on three grabs. Darnell Washington added 27 yards and one touchdown on three catches, and Pat Freiermuth chipped in three catches for 17 yards and 1 score
Key Injury Report for Pittsburgh:
- Michael Pittman Jr. (Expected Out) – Foot
- Jalen Ramsey (Questionable) – Wrist
- DeShon Elliott (Questionable) – Knee
- Rico Dowdle (Questionable) – Toe
Indianapolis Colts vs Pittsburgh Steelers Picks and Prediction
Pick: Pittsburgh Steelers -3 (-102)
Pittsburgh will have an opportunity to get back in the win column Sunday when Indianapolis comes to town. The Steelers suffered a disappointing loss to Cleveland last week and will need a stronger defensive performance against a Colts team coming off an impressive victory. Indianapolis has enough offensive talent to challenge Pittsburgh, but the Colts will need to handle the pressure of playing in a difficult road environment. The Steelers should look to establish their running game and keep Indianapolis from creating too many scoring opportunities. Pittsburgh also has the defensive personnel to make things difficult for the Colts and force mistakes. The home-field advantage could play a significant role in this matchup, and the Steelers should be able to make enough plays to secure a close victory.
Pick: Under 43.5 (-105)
A physical AFC matchup could be on the way Sunday afternoon when Indianapolis and Pittsburgh meet at Acrisure Stadium. The Steelers will look to bounce back defensively after allowing 27 points to Cleveland, while the Colts will try to continue the success they had against Washington. Pittsburgh should focus on controlling the football and limiting the number of opportunities for the Indianapolis offense. The Colts have enough talent to score, but moving the football consistently against the Steelers could prove difficult. Both teams should have stretches where their offenses struggle to sustain drives, especially if the defenses create pressure in the backfield. Expect a competitive game that stays close throughout the afternoon, with the combined scoring finishing under the total.