Indianapolis Colts vs Seattle Seahawks Prediction and Picks - December 14, 2025
Sunday afternoon NFL action, and we have an Indianapolis Colts vs Seattle Seahawks prediction locked and loaded for you. The Colts are in a bad way as they just lost their starting QB for the season, are off a 36-19 loss to Jacksonville, and are now just 8-5 on the year. Seattle comes in at 10-3 on the year, and they are off a 37-9 road win over the Falcons. These teams last met in 2021, and the Seahawks won that game on the road by a score of 28-16. Read on to see our Colts vs Seahawks prediction.
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Can Philip Rivers Get The Colts To The Postseason?
The Colts’ most recent game was a 36–19 loss to the Jacksonville Jaguars on December 7, where Riley Leonard was forced into action after Daniel Jones went down early with a torn Achilles. Leonard threw for 145 yards with one interception and added a late rushing touchdown, but the offense never found rhythm against Jacksonville’s defense. Jonathan Taylor managed 74 yards and a score, while Alec Pierce led the receiving corps with 80 yards, but the Colts fell behind quickly and couldn’t recover.
Offensively, Indianapolis still ranks among the league’s best, averaging 368.5 yards per game (6th) and scoring 28.9 points per game (5th). Taylor has been the engine, leading the NFL with 1,356 rushing yards and 16 touchdowns. Michael Pittman Jr. and Tyler Warren have combined for over 1,300 receiving yards, giving the Colts balance when healthy. But the quarterback situation is dire: Daniel Jones is out for the season, and the team has turned to Philip Rivers, who was signed out of retirement this week. At 44, Rivers brings experience but limited mobility, and with Leonard nursing a knee injury, the Colts’ passing game is in flux heading into Seattle.
Defensively, the Colts allow 344.9 yards per game (22nd) and have struggled against the pass, ranking 28th at 246.3 yards allowed per game. The run defense has been stout, giving up just 98.6 yards per game (6th), but injuries have weakened the unit. Linebacker Germaine Pratt has been a steady presence with 98 tackles, while Laiatu Latu has added 5.5 sacks and three interceptions. Still, the secondary has been exposed repeatedly, and facing Seattle’s deep receiving corps will be a major challenge. With Jones sidelined and Rivers stepping in cold, the Colts’ defense will need to play above its ranking to keep them competitive.
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Seattle Has No Problem With Atlanta
Seattle’s most recent game was a 37–9 win over the Atlanta Falcons on December 7, where Sam Darnold threw for 249 yards and three touchdowns. Jaxon Smith-Njigba was the star, catching seven passes for 92 yards and two scores, while Rashid Shaheed electrified with a 100-yard kickoff return to open the second half. The Seahawks broke open a tight game with 17 points in the third quarter and coasted to their 10th win of the season.
Offensively, Seattle averages 353.5 yards per game (9th) and scores 29.8 points per game (2nd), one of the league’s most explosive attacks. Darnold has thrown for 3,162 yards and 22 touchdowns, while Smith-Njigba leads the NFL with 1,428 receiving yards. Kenneth Walker III and Zach Charbonnet provide balance in the backfield, combining for over 1,200 rushing yards and 12 touchdowns. The only concern has been turnovers, with 23 giveaways ranking 31st, but the sheer firepower of the passing game has masked those mistakes.
Defensively, Seattle has been outstanding, allowing just 288.2 yards per game (6th) and 17.4 points per game (2nd). Their run defense ranks 4th at 91.2 yards per game, while the secondary has held opponents to 197.1 passing yards per game (11th). Ernest Jones has been a playmaker with five interceptions, while Leonard Williams and Demarcus Lawrence anchor a pass rush that has combined for over a dozen sacks. Injuries are minimal, with no players listed on the official report as of December 12, giving Seattle a clean bill of health heading into this matchup. With the Colts scrambling at quarterback, the Seahawks’ defense is well-positioned to dominate.
Indianapolis Colts vs Seattle Seahawks Pick
Colts vs Seahawks Spread Pick
- Indianapolis +14 (4 Units)
Taking the points with Indianapolis +14 has merit given the circumstances and the way this matchup sets up. The Colts are coming off a 36–19 loss to Jacksonville on December 7, where Daniel Jones tore his Achilles early and Riley Leonard had to step in. That injury forced the team to sign veteran Philip Rivers out of retirement, and while he’s not the same player he once was, his experience and ability to manage an offense could stabilize things. Jonathan Taylor remains the centerpiece, leading the league in rushing yards and touchdowns, and his presence gives Indy a chance to control tempo even against Seattle’s stout run defense. With Taylor pounding the ball and Rivers leaning on Michael Pittman Jr. and Alec Pierce, the Colts have enough offensive talent to keep this within two scores.
Seattle is coming off a 37–9 rout of Atlanta on December 7, where Sam Darnold threw three touchdowns and Jaxon Smith-Njigba continued his monster season. The Seahawks are explosive, averaging nearly 30 points per game, but they’ve also been turnover-prone with 23 giveaways, ranking 31st in the league. That volatility opens the door for Indianapolis to hang around, especially if their defense can force mistakes. The Colts’ run defense is top-10, and if they can slow Kenneth Walker III and Zach Charbonnet, it puts more pressure on Darnold to stay clean. Getting two full touchdowns in a game where Indy still has elite pieces and Seattle has shown a tendency to cough up the ball makes the +14 worth grabbing.
Colts vs Seahawks Over/Under Pick
- Under 43 (5 Units)
The Under 43 looks like the right angle in Colts–Seahawks given the quarterback situation for Indianapolis and the defensive strength on both sides. The Colts are coming off a 36–19 loss to Jacksonville on December 7, where Daniel Jones tore his Achilles and the offense sputtered under Riley Leonard before signing Philip Rivers out of retirement. Even with Jonathan Taylor leading the league in rushing, the passing game is in flux, which limits Indy’s scoring ceiling. Seattle, meanwhile, just beat Atlanta 37–9 on December 7, and their defense has been elite all season, ranking 6th in total yards allowed (288.2) and 2nd in points allowed (17.4). With the Seahawks’ ability to clamp down and the Colts adjusting to a new quarterback, this matchup sets up for a slower, grind-it-out style that favors the Under 43.
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