Jacksonville Jaguars vs. Arizona Cardinals Prediction and Picks for Sunday, November 23rd, 2025
The Jacksonville Jaguars (6-4) occupy the final AFC wild card spot entering Week 12, and they’ll try to secure another important win when they head out west to take on the sliding Arizona Cardinals (3-7). We’ve got you covered with our Jaguars vs. Cardinals prediction. Kickoff is scheduled for 4:05 ET from State Farm Stadium in Glendale, AZ. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Jaguars Hammer the Chargers
The 6-4 Jacksonville Jaguars play in a very winnable division, but with the emergence of the 8-2 Colts, an AFC South title is likely out of the question at this point. From a sports betting perspective, Jacksonville is priced at +425 to win the South and -200 to make the playoffs. In terms of recent form, the Jaguars are in the midst of an underwhelming 2-3 run, but they are coming off of a solid 35-6 victory over the Chargers. Jacksonville has gone 5-5 ATS and they’ve also split their totals 5-5 to the over/under.
In terms of personnel, it’s Trevor Lawrence leading the offense again this season. He has thrown for 2,151 yards on a 59.8% completion rate, adding 11 touchdowns and eight interceptions. RB Travis Etienne Jr., who is dealing with a shoulder injury and has an “unspecified” game designation, leads the rushing attack with 729 yards and five touchdowns on 154 carries (4.7 YPC). The Jags are banged up out wide as well, so look for WR Parker Washington (350 yards, 2 TD) to be Lawrence’s top target in the passing game.
- Offensively, the Jaguars are scoring 24.0 points per game (13th), while averaging 326.9 yards per week (19th).
- Defensively, they are 12th in the NFL this year, conceding 22.6 points per game. They’re allowing 323.6 yards per contest, which is 14th.
- Injury Report: Each of the following players is confirmed out for Sunday: WR Brian Thomas Jr. (ankle), TE Hunter Long (hip/knee), OL Anton Harrison (knee/ankle), DE Travon Walker (knee), and LB Yasir Abdullah (finger). These players are questionable: CB Jarrian Jones (quad), CB Jourdan Lewis (neck), and TE Brenton Strange (hip). WR/CB Travis Hunter (knee) is out for the season and was placed on the IR on Nov. 16.
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Cardinals Just 1-7 in Last Eight Games
The expectations were high for the Arizona Cardinals this season, and Coach Jonathan Gannon’s group got off to a nice 2-0 start. However, the wheels have completely fallen off, as the Cardinals are in the midst of a 1-7 stretch, including two straight losses to the Seahawks (44-22) and the 49ers (41-22), more recently. Arizona is now 3-7 overall, which puts them in 12th place in the NFC. They’re priced at +10000 just to make the playoffs. As for the game-by-game betting numbers, the Cardinals have gone 5-5 ATS and 6-4 to the over.
With QB Kyler Murray (foot) moving to IR, Jacoby Brissett has inherited the offense. He has been serviceable, throwing for 1,570 yards on a 66.7% completion rate, adding 10 touchdowns and three interceptions. TE Trey McBride continues to excel in the passing game, hauling in 71 receptions for 718 yards and seven touchdowns. The running backs room has been an infirmary this year, and it’s currently Bam Knight (181 yards, 3 TD) sitting atop the depth chart.
- Arizona’s offense has been subpar this season, ranking 19th in scoring (22.4 PPG), while putting up 333.5 yards per game (14th).
- On the defensive side, the Cardinals are 25th this season, allowing 25.6 points per game. In terms of yardage, they’re 21st, conceding 333.6 yards per contest.
- Injury Report: The following players didn’t practice at all on Thursday for Arizona: OT Kelvin Beachum (groin), LB Baron Browning (concussion), RB Emari Demercado (ankle), WR Marvin Harrison Jr. (illness), SAF Dadrion Taylor-Demerson (ankle), and OT Jonah Williams (shoulder).
Jaguars vs. Cardinals Pick
Spread Pick and Prediction for Jaguars vs. Cardinals
- Jacksonville Jaguars -2.5 (-111) (5 units)
The Cardinals have gone an embarrassing 1-7 SU in their eight games. Five of those seven losses have come by 3+ points, so I will gladly fade them while this spread is still inside of a field goal.
There’s a big mismatch with Jacksonville’s offense vs. Arizona’s defense in this game. The Jags have scored 29+ points in each of their last three games, while the Cardinals are allowing an average of 27.6 points per contest during their 1-7 SU run. I don’t anticipate the Cardinals doing a whole lot offensively-which I’ll dive into below-so as long as the Jags are semi-productive on the offensive side, then they should take care of business. Give me Jacksonville to cover.
Over/Under Pick for Jags vs. Cardinals
- Under 47.5 (-110) (5 units)
I think this will be a relatively easy day at the office for Jacksonville’s defense. They’ve been fantastic against the run this season, allowing only 86.7 yards per game (second) and 3.96 yards per attempt (ninth). With Arizona’s backfield still banged up and averaging only 105.7 rushing yards per game (24th), Jacksonville should be able to focus on shutting down their depleted passing attack.
And on the flip side, I expect to see the Jaguars find some success offensively, but I don’t think they’ll explode for 35+ points. They’re just 27th in yards per play (4.96) this season, and they have countless injuries of their own to deal with. With Arizona having the home-field edge, their defense may at least turn in a serviceable outing. I’ll play the under, and I expect to see this game land in the 24-17 range.
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