Las Vegas Raiders vs New Orleans Saints Picks and Prediction for Sunday September 27 2026

The Las Vegas Raiders visit the New Orleans Saints at Caesars Superdome in New Orleans, Louisiana, on Sunday, September 27, 2026. Kickoff is scheduled for 4:25 PM ET. Las Vegas enters Week 3 after an impressive 26-14 road victory over the Los Angeles Chargers, while New Orleans is coming off a 24-17 road win over Baltimore. The Saints are favored by 3.5 points with the total set at 44.5. Be sure to check out our free NFL picks for more NFL predictions throughout the season.

Las Vegas Arrives With Momentum

Las Vegas produced one of the more impressive road results of Week 2 by beating the Chargers 26-14. The Raiders controlled the game well enough to win by double digits and now have another road opportunity against a New Orleans team coming off an impressive victory of its own.

The Raiders’ ability to score 26 points is encouraging heading into a matchup with a total in the mid-40s. Las Vegas does not necessarily need another performance at that level to cover. With 3.5 points in hand, keeping New Orleans somewhere in the low 20s could put the Raiders in an excellent position.

The challenge is handling a Saints team returning home with considerable confidence. Las Vegas cannot count on New Orleans making the same mistakes the Chargers did. The Raiders need another composed road performance and must avoid turnovers that could allow the Superdome crowd to become a factor.

New Orleans Returns Home After a Statement Road Win

New Orleans earned one of Week 2’s more notable victories by going into Baltimore and winning 24-17. That result carries weight because the Saints showed they could handle a difficult road environment while keeping the Ravens from creating the type of offensive rhythm many expected.

Now New Orleans returns to Caesars Superdome as a modest favorite. The Saints’ defensive performance against Baltimore is particularly encouraging against a Raiders team that just scored 26 points. If New Orleans can again keep its opponent below 20, the Saints should have a strong opportunity to improve their record.

The betting question is whether New Orleans should be laying more than a field goal against another team coming off an impressive victory. The Saints deserve to be favored, but Las Vegas showed enough last week to make 3.5 meaningful. A three-point New Orleans victory would be enough for the Saints on the scoreboard but not for bettors laying the current spread.

Las Vegas Raiders vs New Orleans Saints Picks and Prediction

Pick: Las Vegas Raiders +3.5

Las Vegas +3.5 is the side pick. New Orleans deserves respect after winning in Baltimore, but the Raiders are also coming off a double-digit road victory. Getting more than a field goal provides valuable protection in a matchup between teams that played well last week. New Orleans can win a close game at home while Las Vegas still covers, making the points preferable to laying 3.5.

Pick: Under 44.5

Under 44.5 is the total pick. New Orleans held Baltimore to 17 points, while Las Vegas limited the Chargers to 14. Both teams showed the ability to win with defense last week, and neither needs to turn this into a high-tempo shootout. A game around 23-20 or 24-17 fits the recent form and keeps the combined score below 44.5.

Final Picks: Las Vegas Raiders +3.5 and Under 44.5