Los Angeles Chargers vs. Jacksonville Jaguars, Picks, Odds, Preview and Prediction, Sunday, Nov. 16, 2025
Use Code SSWC A pair of second-place AFC teams meet up in Florida on Sunday, and we’re getting you ready for the action with Chargers vs. Jaguars predictions. Los Angeles (7-3 SU, 4-5-1 ATS) picked up a 25-10 victory over Pittsburgh at home last Sunday as -3 favorites. Jacksonville (5-4 SU, 4-4-1 ATS) fell at Houston last weekend, 36-29, as +1 underdogs. Kickoff from EverBank Stadium is scheduled for 1:00 EST. If you need more quality winners, this is the ultimate site for NFL Picks.
Chargers staying stable
The Chargers have won three straight games to stay a game behind red-hot Denver in the AFC West. In their win over Pittsburgh, the defense allowed only 10 points for the second time in their last three games, and the offense was able to make a 12-3 halftime lead hold up.
The team is averaging 29.7 points during their current winning streak, and on the year, they are putting up 24 points per game, eighth best in the NFL. Their total offense averages 368.5 yards per game, also eighth in the league, behind the league’s seventh-best pass offense which is averaging 245.4 yards a game. Justin Herbert has thrown for at least 220 yards in each of his last five games, and his 2,610 yards this season are the third most in the league. The Chargers’ QB has 19 TDs, 8 INTs and has been sacked 33 times. Ladd McConkey has 51 catches for 631 yards and Keenan Allen has 52 catches for 539 yards. L.A.’s run game averaged 123.1 yards per game, led by Kimani Vidal’s 404 yards on 91 carries. Herbert is second on the team with 324 rushing yards.
The Los Angeles scoring defense ranks eighth in the NFL, allowing 20.3 points per game. The 280.2 total yards per game that they allow is the fourth-best average in the league. They have the fifth-best passing defense, allowing 174.2 yards per game. Against the run, they are giving up 106 yards per game, 13th overall. Chargers’ defenders have gotten to the opposing QB for 29 sacks, and the team is tied for fifth in the league with 10 interceptions. Tuli Tuipulotu leads the team and is tied for fifth in the league with 8 sacks. Daiyan Henley leads the team with 67 tackles.
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Injury report
- CB Tarheeb Still (knee) is questionable
- WR Quentin Johnson (shin) is questionable
- CB Elijah Molden (knee) is questionable.
- RB Omarion Hampton (ankle is on the IR
- OT Joe Alt (ankle) is on the IR.
Jaguars taking steps back
The Jaguars are in the middle of a run of four road games in five weeks, and after opening with a win in Vegas, they fell in Houston last week before returning home. They were in firm control last weekend, leading 29-10 before allowing the Texans to outscore them, 26-0, in the fourth quarter.
Jacksonville’s defense has allowed at least 29 points in each of their last three games. They rank 20th in the league in scoring defense, allowing 24.4 points per game this season. The 344.6 total yards per game allowed ranks 23rd overall. They actually have the fifth-best run defense in the league, allowing just 91.7 yards per game, but versus the pass they are giving up 252.9 yards per game, fifth most overall. The Jags are second in the NFL with 12 interceptions, but are tied for last with 12 sacks. Devin Lloyd is tied for the league lead with 4 interceptions and his 129 yards on those picks lead the league. Foyesade Oluokun leads the team with 75 tackles, tied for 17th most in the league.
Jacksonville is 1-3 SU over their last four games as the offense averaged 19.5 points per game. This season, the team is putting up 22.8 points per game, 18th in the league. They are gaining 324.9 total yards per game, the 14th-lowest average in the NFL. Their rushing game ranks 14th, averaging 120.3 yards per game. Travis Ettienne Jr. is 12th in the league with 656 yards on the ground. The Jags' passing attack ranks 19th with 204.6 yards per game. Trevor Lawrence had his worst game of the season last week, completing just 56.5 passes for 158 yards. The Jags’ QB has 1,998 passing yards on the year with 10 TDs, 7 INTs and 26 sacks. Brian Thomas Jr, who leads the team with 30 catches and 420 yards, did not play last week and is questionable for this game.
Injury report
- CB Jourdan Lewis (neck) is out.
- OT Anton Harrison (knee/ankle) is out.
- TE Hunter Long (hip/knee) is out.
- WR Brian Thomas (ankle) is questionable.
Chargers vs. Jaguars Picks
Spread Pick for Chargers vs. Jaguars
- Chargers -3 (5 units)
These two last met in 2023, a game the Jags won by a point at home. The teams are headed in different directions heading into this matchup, as Jacksonville continues to spiral after a 4-1 SU start. They averaged 9.5 points in their last two home games, both against top 10 defenses, which the Chargers also bring to the table. The Jags have question marks across most of their starting offensive line and even in their depth. They are also banged up in the wide receiver department, and Lawrence looked lost last week without his top target, Thomas, on the field. The Chargers have themselves a very good head of steam and a bye week following this, so they’ll be looking to go all out here. Their current three-game winning streak has come with a 13-point margin of victory per game. They are also 3-1 SU on the road this season, with the wins coming by an average of 6.7 points per game. Los Angeles is 7-3 SU and 8-2 ATS in the last ten meetings between these two.
Take the Chargers.
Over/Under Pick for Chargers vs. Jaguars
- Over 44.5 (5 units)
These two combined for 61 points when they met two years back, crushing the over against a 46.5-point total. The offenses on these two teams rank in the middle of the league in terms of scoring, each averaging over 22 points per game. Los Angeles has been in great shape of late, scoring at least 24 points in five straight games, with 27 or more in three of those. I fully expect Herbert to move the Chargers offense up and down the field all night, so they should have plenty of scoring chances. The Jags scored at least 26 points in four of their last six efforts. This could be a good chance for them to get Ettienne back on track, and if Jacksonville gets the run game established, the points should follow. The over is 8-2 in the last ten games between these two teams.
Take the over.
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