Los Angeles Chargers vs. New York Giants Prediction and Picks for Sunday, September 28th, 2025
Use Code SSWC Sunday’s early slate of games features an intriguing cross-conference clash between the Los Angeles Chargers (3-0) and the New York Giants (0-3). We’ve got you covered with our Chargers vs. Giants prediction. Kickoff is scheduled for 1:00 ET from MetLife Stadium in East Rutherford, NJ. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Chargers Sit Atop the AFC West
The Los Angeles Chargers are in their second season under Jim Harbaugh, and the team is looking to build on an 11-6 campaign where they made it to the wild card round. So far in 2025, the Chargers have looked sharp, going 3-0 out of the gate. They’ve taken down the Chiefs (27-21), Raiders (20-9), and Broncos (23-20), and that’s good enough to put them atop the AFC West standings. Los Angeles is priced at -150 to win the division, while sitting at +1500 to win the Super Bowl.
In terms of personnel, it’s Justin Herbert once again under center for the Chargers this season. The signal caller has looked good, throwing for 860 yards on a 66.7% completion rate, adding six touchdowns and one interception. WR Quentin Johnston is having a breakout year, hauling in 14 passes for 239 yards and three touchdowns. With Najee Harris (Achilles) sidelined for the rest of the year, it’ll be rookie running back Omarion Hampton handling the rushing workload. He has 142 yards and a touchdown on 42 carries (3.4 YPC).
- Offensively, the Chargers are scoring 23.3 points per game (14th), while averaging 362.3 yards per week (sixth).
- Defensively, they are third in the NFL this year, conceding 16.7 points per game. They’re allowing 276.7 yards per contest, which is eighth.
- Injury Report: The latest injury report from the Chargers states that each of the following players did not practice (DNP) on Thursday: G Mekhi Becton (concussion), WR Derius Davis (knee), and TE Will Dissly (knee). Both C Bradley Bozeman (back) and DB Elijah Molden (hamstring) were limited participants.
Giants Slide To 0-3
Meanwhile, there’s already some early-season turmoil for the New York Giants. But honestly, when isn’t there? This team has made the playoffs just once in the last seven seasons. As for the 2025 campaign, Coach Brian Daboll’s squad is off to an 0-3 start. They’ve dropped games to the Commanders (21-6), Cowboys (40-37), and Chiefs (22-9), most recently. New York’s updated win total heading into week 4 is just 4.5 wins (-130/+110).
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I may have buried the lead, but it was announced earlier in the week that Coach Daboll will be turning to rookie quarterback Jaxson Dart to take the reins of the offense from Russell Wilson. Dart was drafted out of Ole Miss, where he threw for 4,278 yards and a 29/6 TD/INT ratio last season, leading the team to a 10-3 campaign. Additionally, rookie RB Cam Skattebo (102 yards, 2 TD) will take over in the backfield with lead rusher Tyrone Tracy Jr. (shoulder) sidelined for a few weeks.
- New York’s offense has been disappointing this season, ranking 27th in scoring (17.3 PPG), while putting up 339.3 yards per game (12th).
- On the defensive side, the Giants are 24th this season, allowing 27.7 points per game. In terms of yardage, they’re 31st, conceding 405.3 yards per contest.
- Injury Report: The Giants had several DNPs on Thursday: K Graham Gano (groin), DT Rakeem Nunez-Roches (foot), RB Tyrone Tracy Jr. (shoulder), and DE Chauncey Golston (ankle). Notable players that were limited include: WR Malik Nabers (shoulder). WR Darius Slayton (calf), and OT Andrew Thomas (foot).
Chargers vs. Giants Pick
Spread Pick for Chargers vs. Giants
- Los Angeles Chargers -6.0 (-110) (5 units)
I would love to try and make a case for the Giants as underdogs in this spot, because the truth is that 6.0 points is a lot of points to lay on the road. That’s especially true for a team like the Chargers, which has typically been a run-first, grind-it-out type of team under Coach Jim Harbaugh.
However, there are enough anti-Giants data points to make a case for the Bolts covering this large number on the road. First, it’s that New York’s defense has been horrid this season. They’re allowing 27.7 points per game ,and they’re one of two teams conceding more than 400 yards per contest! With Los Angeles’ Quentin Johnston establishing himself and the Chargers now possessing a deep passing game, it stretches the field and should allow their offense to feast on Sunday. Factor in that the Giants will roll with a debuting rookie quarterback against a top-five defense, and you can start to see the path for a Bolts win of 7+ points.
Over/Under Pick for Chargers vs. Giants
- Under 43.5 (-110) (5 units)
I’m going to pick it right back up with the rookie quarterback making his debut on Sunday for the G-Men. Jaxson Dart looked solid in the preseason, but now he’ll be tasked with trying to navigate a Harbaugh-Minter Los Angeles defense that’s one of the best in the league. Good luck. They’re allowing only 16.7 points per game this season and Pro Football Focus has their secondary graded as the third-best unit in the NFL through three weeks.
I don’t anticipate the Giants finding much offensive success on Sunday, and when coupling that with the fact that the Chargers still have their foundation in running the football (which leads to a running clock), I think we see this game finish under the total. I’ll predict 27-13 in favor of the Bolts.
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