Los Angeles Rams vs Arizona Cardinals Picks and Prediction for Sunday November 15 2026

The Rams head to Glendale on Sunday for a 4:05 PM ET game against Arizona at State Farm Stadium. Los Angeles opened as a 7.5-point favorite, with the total at 44.5, although both numbers have been moving during the week. The stadium has a retractable roof, and its operating status hasn’t been confirmed. Outside, the forecast is around 74 degrees, with light winds and almost no chance of rain. Weather shouldn’t be a problem. The Rams have been moving the football well, while Arizona just managed three points against Seattle. I like Los Angeles, but this spread is getting into dangerous territory. With the NFL season heating up you should make sure you are fully prepared with our free NFL picks.

The Rams Have Been Moving the Football

Los Angeles is 5-4 after beating Washington 20-13 on Sunday. That wasn’t a spectacular offensive performance, but the Rams got the job done. They’ve been inconsistent this season, yet they’ve shown they can move the football against good defenses. The question is whether they can turn those yards into touchdowns. Against Arizona, they should have opportunities.

The Rams are averaging 23.8 points and 379.8 yards per game. That’s the fourth-best yardage average in football. Los Angeles has been moving the ball much better than its scoring average suggests. The offense needs to finish drives because Arizona has been struggling to score. The Rams also need to avoid turnovers. Give the Cardinals short fields, and suddenly a game that should be comfortable becomes difficult.

Matthew Stafford has been directing the offense, and the Rams need him to make good decisions against Arizona’s defense. Los Angeles has enough receiving talent to create mismatches, but the offensive line has to provide protection. The Rams also need to establish the run. If Arizona can sit back in coverage all afternoon, Stafford could have to work harder than expected.

Arizona Has Been Struggling to Score

Arizona is 3-6 after losing 17-3 to Seattle on Sunday. That’s a pretty ugly offensive performance. The Cardinals couldn’t get anything going, and the Seahawks controlled the game defensively. Arizona has been competitive at times this season, but the offense has been too inconsistent. Now the Cardinals have to face a Rams team that’s been moving the football well.

Arizona is averaging 19.8 points and 318 yards per game. That’s not enough offense to consistently win games. The Cardinals have been controlling possession reasonably well, but they haven’t been finishing drives. That’s a problem against Los Angeles because the Rams can score quickly when the offense gets into rhythm. Arizona needs to get something going on the ground and avoid making every possession depend on the quarterback.

The Cardinals need better protection and more production from their receiving group. They also need their defense to create turnovers. That’s probably their best chance to keep this close. Arizona can’t afford to fall behind by two touchdowns because the offense hasn’t been good enough to consistently come back. The Cardinals need to play from ahead or at least keep the game within one score.

Los Angeles Rams vs Arizona Cardinals Picks and Prediction

Spread Pick: Los Angeles Rams -7.5

I’m taking the Rams and laying the 7.5 points, although I wouldn’t chase this number much higher. Arizona just scored three against Seattle, and the Cardinals have been struggling offensively. Los Angeles is generating almost 380 yards a game, which should be enough to create scoring opportunities against Arizona. The concern is the Rams settling for field goals and letting the Cardinals hang around. But I think Los Angeles has enough offensive talent to win by double digits.

Total Pick: Under 44.5

I’ll take the under 44.5. Arizona has been scoring fewer than 20 points a game, and the Cardinals just managed three against Seattle. The Rams can move the football, but they’ve also had trouble turning yards into points. If Los Angeles gets a lead, I expect the Rams to run the ball and keep the clock moving. The biggest danger is Arizona giving up a couple of big plays and forcing the Rams to score more than expected. But I think this stays relatively controlled. Something around 27-13 Los Angeles makes sense.

Final Picks: Los Angeles Rams -7.5 | Under 44.5