Los Angeles Rams vs Arizona Cardinals Prediction and Picks - December 7, 2025
National Football League action on Sunday afternoon, and we have a Los Angeles Rams vs Arizona Cardinals prediction locked and loaded for you. The Rams enter this game off a 31-28 road loss to Carolina, falling to 9-3 on the year. Arizona comes in off a 20-17 loss at Tampa Bay, and they are now 3-9 on the season. Read on to see our Rams vs Cardinals prediction.
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Rams Suffer Stunning Loss At Carolina
The Rams’ most recent game was a 31–28 loss to the Carolina Panthers on November 30, where Matthew Stafford threw for 243 yards and two touchdowns but also committed three turnovers, including a costly pick‑six that swung momentum. The defeat snapped a six‑game winning streak and reminded Los Angeles that even elite teams can stumble when mistakes pile up.
Offensively, the Rams remain one of the league’s most efficient units, averaging 360.1 yards per game (8th) and 27.8 points per game (6th). Stafford has been sharp overall, throwing for 3,073 yards with 32 touchdowns and just four interceptions, while Puka Nacua continues to shine with over 1,000 receiving yards. Kyren Williams provides balance with 868 rushing yards and seven touchdowns, and Davante Adams has been a red‑zone force with 14 scores. The Rams have committed only 11 turnovers (9th fewest), a key factor in their success.
Defensively, Los Angeles has been stout, ranking 2nd in points allowed (17.5 per game) and 13th in total defense (315.1 yards allowed). Byron Young leads the pass rush with 10 sacks, while Kamren Kinchens has added two interceptions in the secondary. Injuries, however, are a concern: CB Darious Williams (tibia, doubtful), DT Poona Ford (calf, questionable), and WR Tutu Atwell (hamstring, IR) headline the list. With several starters banged up, the Rams will need their depth to step up against a divisional rival.
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Cardinals Fall Short In Tampa
The Cardinals’ most recent game was a 20–17 loss to the Tampa Bay Buccaneers on December 1, where Jacoby Brissett threw for 293 yards and two touchdowns but couldn’t complete a late drive to tie the game. It was Arizona’s fourth straight defeat, dropping them to 3–9, and underscored how close they’ve been without finding ways to finish.
Offensively, Arizona averages 337.3 yards per game (16th) and 22.1 points per game (20th). Brissett has been steady, completing 67.5% of his passes for 2,188 yards, 13 touchdowns, and four interceptions. Tight end Trey McBride has been the focal point with 879 receiving yards and eight touchdowns, while Marvin Harrison Jr. has added 594 yards and four scores but is now sidelined with a heel injury. The run game has been inconsistent, ranking 24th at 100.6 yards per game, with Bam Knight and Michael Carter splitting duties in the absence of Trey Benson.
Defensively, the Cardinals have struggled, allowing 25.3 points per game (24th) and ranking 19th in total defense (332.2 yards allowed). Josh Sweat leads the pass rush with 11 sacks, while Budda Baker anchors the secondary. Injuries are extensive: QB Kyler Murray (foot, out for season), WR Marvin Harrison Jr. (heel, out), RB Trey Benson (knee, out), WR Greg Dortch (chest, out), and CB Max Melton (heel, out) headline a long list. With so many playmakers unavailable, Arizona faces an uphill battle against one of the NFC’s top contenders.
Los Angeles Rams vs Arizona Cardinals Pick
Rams vs Cardinals Spread Pick
- Arizona +9 (4 Units)
Taking Arizona +9 has some appeal because even in their 20–17 loss to Tampa Bay, the Cardinals showed they can hang around against stronger opponents. Jacoby Brissett threw for nearly 300 yards and two touchdowns in that game, and Trey McBride continues to be a reliable weapon with 879 receiving yards on the season. Even with Marvin Harrison Jr. sidelined, Arizona still averages 337.3 yards per game and has enough passing punch to test a Rams defense that has been strong but occasionally vulnerable against tight ends and slot receivers. Getting nine points gives them room to absorb mistakes while still staying within striking distance.
The other angle is the divisional familiarity. The Rams are clearly the more complete team, averaging 27.8 points per game and ranking second in points allowed (17.5 per game), but Arizona knows how to muddy these matchups. The Cardinals’ defense has struggled overall, giving up 25.3 points per game, yet they’ve been competitive enough to force opponents into longer drives. With the Rams coming off a turnover‑filled loss to Carolina, there’s reason to believe Arizona can capitalize on mistakes and keep this closer than expected. In a rivalry game where emotions run high, taking the nine points with the Cardinals feels like a solid play.
Rams vs Cardinals Over/Under Pick
- Over 47.5 (5 Units)
The Over 47.5 looks like a strong angle in Rams–Cardinals because both teams have shown they can put points on the board, and the matchup sets up for offense to shine. The Rams average 27.8 points per game (6th) with Matthew Stafford leading one of the league’s most efficient passing attacks (246.6 yards per game, 4th), while Arizona, even in their 20–17 loss to Tampa Bay, showed Jacoby Brissett can move the ball through the air, throwing for nearly 300 yards. The Cardinals’ defense has been shaky, allowing 25.3 points per game (24th), and Los Angeles has occasionally been vulnerable against tight ends and slot receivers despite ranking 2nd in points allowed. With Trey McBride emerging as a reliable weapon for Arizona and the Rams’ offense capable of striking quickly, this divisional matchup has the right ingredients for a game that pushes past the 47.5 total.
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