Los Angeles Rams vs Denver Broncos Picks and Prediction for Sunday September 27 2026

The Los Angeles Rams visit the Denver Broncos at Empower Field at Mile High in Denver, Colorado, on Sunday, September 27, 2026. Kickoff is scheduled for 8:20 PM ET in the Week 3 Sunday Night Football matchup. Los Angeles enters after a convincing 28-6 Monday night victory over the New York Giants, while Denver comes in after defeating Jacksonville 20-13. The Rams are favored by 2.5 points with the total set at 45.5. Be sure to check out our free NFL picks for more NFL predictions throughout the season.

Los Angeles Takes Its Momentum to Denver

The Rams are coming off a dominant Monday night performance in which they beat the Giants 28-6. Los Angeles controlled the game defensively and created enough offensive separation that the outcome was never seriously threatened late. That type of balanced performance explains why the Rams are favored despite playing this game in Denver.

The challenge is the turnaround. Los Angeles played Monday night and now travels to altitude for a Sunday night matchup against a Denver team that has had a normal week of preparation. That rest differential is worth considering when deciding whether to lay points with the road favorite.

Still, the Rams showed a strong combination of offense and defense against New York. If they can carry that balance into Denver, they should be capable of winning without needing an explosive offensive performance. The key will be avoiding a slow start that allows the Broncos to control the game through field position and defense.

Denver Has a Chance to Make a Statement at Home

Denver improved its position with a 20-13 victory over Jacksonville. The Broncos did not need a huge offensive performance because their defense kept Jacksonville from generating enough scoring opportunities. That same formula gives Denver a realistic chance against Los Angeles.

Home field is especially important in this matchup. The Rams are traveling on a short week and must deal with Denver’s altitude after playing Monday night. The Broncos, meanwhile, have had the conventional preparation window and should be able to approach this game with an emphasis on controlling tempo.

The question is whether Denver can create enough offense. Twenty points were sufficient last week, but Los Angeles just held New York to six. If the Rams defense travels well, the Broncos may find themselves needing to win another game in which every possession becomes important. That makes taking points at home attractive.

Los Angeles Rams vs Denver Broncos Picks and Prediction

Pick: Denver Broncos +2.5

Denver +2.5 is the side pick. Los Angeles was excellent Monday night, but the Rams now have a short week followed by a trip to Denver for a primetime road game. The Broncos are coming off a victory of their own and have the defensive ability to keep this close. With Denver receiving points at home, the situational advantages are enough to take the underdog rather than ask Los Angeles to win by a field goal.

Pick: Under 45.5

Under 45.5 is the total pick. Denver’s Week 2 game finished with only 33 combined points, while the Rams allowed six in their Monday night victory. Both teams have demonstrated that they can lean on their defenses rather than become dependent upon high-scoring games. Denver should also prefer a controlled pace that reduces the Rams’ opportunities. A 23-20 or 24-17 type of game makes the Under the preferred play.

Final Picks: Denver Broncos +2.5 and Under 45.5