Philadelphia Eagles vs. Kansas City Chiefs Picks and Prediction for Sunday, September 14, 2025
The marquee matchup in the NFL this weekend features a Super Bowl rematch between the Philadelphia Eagles (1-0) and the Kansas City Chiefs (0-1). We’ve got you covered with our Eagles vs. Chiefs prediction. Kickoff is scheduled for 4:25 ET from Arrowhead Stadium in Kansas City, MO. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Eagles Sneak Past Cowboys in Week 1
The Philadelphia Eagles are coming off a Super Bowl-winning campaign where they destroyed the Chiefs in a 40-22 affair last February. Coach Nick Sirianni and his squad are near the top of the betting board to repeat as champions, and they can be found as high as +750 to hoist the Lombardi again. Under Sirianni, the recently promoted Kevin Patullo leads the offense, while longtime coordinator Vic Fangio handles the defensive coaching.
The Eagles got the season started with a quality home win over the Cowboys, beating them 24-20. Philadelphia closed as 7.5-point favorites, so they did not cover the number. Jalen Hurts (152 passing yards) didn’t have a huge day through the air, but he was the leading rusher with 62 yards and two touchdowns. Superstar running back Saquon Barkley added 60 yards and a touchdown on 18 carries (3.3 YPC). Out wide, Jahan Dotson (59 yards) emerged as the top receiver, while DeVonta Smith (16 yards) and A.J. Brown (8 yards) weren’t very involved.
- Philadelphia scored 24 points in week 1, and that’s just shy of their 2024 average of 29.0 PPG (fifth).
- On the defensive side, they were fantastic in 2024, ranking first in both points against (18.1 PAPG) and yards allowed per contest (288.6).
- Injury Report: As of this writing (Friday afternoon), the latest available injury report (Thursday’s) doesn’t have any game designations. However, TE Dallas Goedert (knee), QB Tanner McKee (right thumb), and RB Will Shipley (oblique) didn’t practice on Thursday.
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Chiefs Return From Brazil Winless
Meanwhile, the Kansas City Chiefs remain the team to beat in the AFC. Coach Andy Reid and his crew have gone to three consecutive Super Bowls, going 2-1 in the Big Game in February. However, Kansas City is getting some disrespect in the betting market this year, sitting at just +1200 to win the Super Bowl. After losing in week 1 to the Chargers (27-21), the Chiefs now own the second-shortest price (+190) to win the AFC West.
Last Friday’s loss to the Bolts came in Sao Paulo, Brazil, in a spot where the Chiefs were 3.0-point favorites. Patrick Mahomes turned in a nice outing, throwing for 258 yards and a touchdown, while adding 57 yards and a touchdown on the ground. His top targets were Hollywood Brown (99 yards), JuJu Smith-Schuster (55 yards), and Travis Kelce (47 yards, 1 TD). Isaiah Pacheco is healthy coming into the season, but he received only five carries and went for 25 total rushing yards.
- The Chiefs managed 21 points in week 1, and they’re coming off of a season where they were 12th in scoring (23.1 PPG) and 19th in yards per game (322.0).
- Defensively, they allowed 20.5 points per game (sixth) and 328.2 yards per contest (10th) in 2024.
- Injury Report: As of Friday’s injury report, WR Xavier Worthy (shoulder) is doubtful and WR Jalen Royals (knee) is out. All other listed players were full participants at Friday’s practice.
Eagles vs. Chiefs Pick
Spread Pick for Eagles vs. Chiefs
- Kansas City Chiefs Moneyline (+105) (5 units)
I do not have the exact number, but one of the most profitable picks in the NFL in recent history is backing Patrick Mahomes as an underdog or favorite of 2.5 points or less. I do know that Mahomes is 11-4 SU as an underdog. With a spread in the pick ‘em range, you’re essentially asking the best quarterback of the current generation to go out and win you a football game. With Mahomes at home and coming off of a loss, I expect the Chiefs to bounce back and take care of business. I will gladly take a plus-money flier on Kansas City in this game.
Kansas City has literally been untouchable at home recently, going 13-0 SU in their last 13 home games. They’ll take on a Philadelphia team that wasn’t disinclined last week, committing nine penalties for 110 yards. The Eagles also conceded 307 total yards and allowed the Cowboys to go 7-11 (63.6%) on third down. Perhaps Philadelphia is the more skillful team, but like I said, I just can’t pass up on a plus-money payout with Kansas City at home.
Over/Under Pick for Eagles vs. Chiefs
- Over 46.5 (-113) (5 units)
This total is pretty much spot-on at this point. These are two of the better defenses in the NFL, but at the same time, this is an offensive-driven league and we have two premier quarterbacks taking the field on Sunday afternoon. When thinking of the range of outcomes, scores of 24-21 and 24-20 feel just a tad low. I’m anticipating enough scoring to see this game sneak over the total and land in the 27-20 or 27-24 range in favor of the Chiefs.
That has been the trend between these two teams, as the over is 4-1 in the last five meetings. Additionally, the Chiefs are mostly healthy offensively and have a very fast receiving group this year. There’s a chance that the speedsters of Hollywood Brown and JuJu Smith-Schuster help reestablish the vertical passing game that Kansas City had several years ago. On the flip side, we just saw Philadelphia put up 24 points on Dallas with DeVonta Smith (16 yards) and A.J. Brown (8 yards) only combining for 24 yards. With two star-studded offenses, I think it’s best to play the over.
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