Philadelphia Eagles vs Los Angeles Chargers Prediction and Picks - December 7, 2025
It's Monday Night Football, and we have a Philadelphia Eagles vs Los Angeles Chargers prediction locked and loaded for you. The Eagles come into this contest off a 24-15 home loss to the Bears to fall to 8-4 on the year. The Chargers check in at 8-4 on the year and they are off a 31-14 home win over the Raiders. Read on to see our Eagles vs Chargers prediction.
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Eagles Look To End Two-Game Slide
The Eagles’ most recent game was a 24–15 loss to the Chicago Bears on November 28, where Jalen Hurts threw for 230 yards and two touchdowns but also tossed a costly interception. Saquon Barkley managed 56 rushing yards on 13 carries, while A.J. Brown hauled in 10 catches for 132 yards, yet the defense was gashed for 281 rushing yards. That defeat marked Philadelphia’s second straight loss and dropped them to 8–4 heading into Monday night.
Offensively, the Eagles have been inconsistent, averaging 304.8 total yards per game (24th) and ranking 23rd in passing yards (196.3). Hurts has thrown for 2,514 yards with 19 touchdowns against just two interceptions, but the passing attack has lacked explosiveness outside of Brown and DeVonta Smith. Barkley has chipped in 740 rushing yards, though the ground game sits 22nd in the league (108.5 per game). Philadelphia scores 22.5 points per game (19th), and while they’ve protected the football well with only eight turnovers (2nd fewest), sustaining drives has been a challenge.
Defensively, the Eagles allow 347.2 yards per game (25th), struggling particularly against the run (128.9 yards allowed, 24th). They’ve been steadier against the pass (218.3 yards allowed, 18th) and rank 9th in points allowed (20.8), but the unit has not consistently controlled the line of scrimmage. Injuries are a factor: DT Jalen Carter (shoulder) and OT Lane Johnson (foot) are out, while Marcus Epps (shoulder) and Myles Hinton (back) are questionable. With the defense missing key pieces up front, Philadelphia will need Hurts and Barkley to carry the load against a tough Chargers defense.
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Chargers Easily Top The Raiders
The Chargers’ most recent game was a 31–14 win over the Las Vegas Raiders on November 30, where Justin Herbert threw two touchdown passes despite breaking a bone in his non‑throwing hand early in the contest. Running back Kimani Vidal exploded for 126 yards and a 59‑yard touchdown run, while the defense limited Las Vegas to just 156 total yards. The victory improved Los Angeles to 8–4 and kept them firmly in the AFC playoff race.
Offensively, the Chargers average 346.8 total yards per game (10th), with Herbert throwing for 2,842 yards, 21 touchdowns, and 10 interceptions. Despite the hand injury, he remains the centerpiece of the attack, supported by Vidal’s 543 rushing yards and a balanced receiving corps led by Ladd McConkey (683 yards, 5 TDs) and Keenan Allen (622 yards, 4 TDs). The ground game ranks 12th (122.1 per game), giving Los Angeles balance, though turnovers have been an issue (14, 17th most). They score 23.1 points per game (18th), a mark that reflects both efficiency and occasional inconsistency.
Defensively, the Chargers have been one of the league’s best, ranking 3rd in total yards allowed (275.3) and 2nd against the pass (168.3). They give up just 21.0 points per game (11th) and have forced 11 takeaways (10th). Injuries loom large, however: Herbert is questionable with the hand injury, while RB Omarion Hampton (ankle) is working back from IR, and TE Tucker Fisk (ankle) is out. Protection will be critical in this game, and the Chargers have used 19 different offensive line combinations this year. Still, Los Angeles enters this matchup with momentum and a defense capable of frustrating Hurts and the Eagles’ offense.
Philadelphia Eagles vs Los Angeles Chargers Pick
Eagles vs Chargers Spread Pick
- LA Chargers +2.5 (4 Units)
The Chargers +2.5 looks appealing because they’re coming off a convincing 31–14 win over the Raiders, where Justin Herbert threw two touchdowns despite playing through a broken bone in his non‑throwing hand, and rookie back Kimani Vidal ripped off a 59‑yard score as part of his 126‑yard day. That victory showcased both their offensive balance and defensive dominance, holding Las Vegas to just 156 total yards. Los Angeles averages 346.8 yards per game (10th) and has a top‑12 rushing attack, which gives them the ability to control tempo against an Eagles defense that has struggled against the run (128.9 yards allowed, 24th). With Herbert still managing to produce and Vidal emerging as a legitimate weapon, the Chargers have the tools to keep this game tight and potentially swing it outright.
The other angle is the Chargers’ defense, which ranks 3rd in total yards allowed (275.3) and 2nd against the pass (168.3), a profile that matches up well against a Philadelphia offense that sits just 23rd in passing yards (196.3). The Eagles have dropped two straight, including a 24–15 loss to Chicago, and while Jalen Hurts has protected the ball well, the offense has been inconsistent outside of A.J. Brown. Los Angeles has forced 11 takeaways (10th) and gives up only 21 points per game (11th), making them one of the more reliable units in the league. With Herbert gutting it out, Vidal providing balance, and the defense capable of frustrating Hurts, grabbing the points with the Chargers feels like the sharper side.
Eagles vs Chargers Over/Under Pick
- Under 42 (5 Units)
The Under 42 feels like the sharper angle because both teams have shown tendencies to grind games down, and the situational trends back it up strongly. Philadelphia has gone 1–6 Under in their last seven Monday Night Football appearances and also 1–6 Under following their loss to Chicago, where the offense sputtered and the defense gave up big rushing plays but still kept the score manageable. The Chargers have mirrored that pattern, sitting 0–6 Under before playing Kansas City and 1–7 Under in their last eight MNF games, a reflection of how their defense often dictates pace while their offense has been streaky. Statistically, the Eagles average just 22.5 points per game (19th) and the Chargers sit at 23.1 (18th), while both defenses rank top‑12 in points allowed, making it unlikely this matchup turns into a shootout. With Herbert nursing a hand injury and the Eagles’ offense struggling to find rhythm outside of A.J. Brown, the setup points toward a slower, possession‑driven game where the Under 42 has strong support.
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