San Francisco 49ers vs Atlanta Falcons Picks and Prediction for Sunday October 25 2026

Mercedes-Benz Stadium will be rocking on Sunday afternoon, when the San Francisco 49ers battle the Atlanta Falcons. This week seven NFL matchup is scheduled for October 25, 2026 at 1:00 pm EST and will be broadcast on FOX. The 49ers are a 3.5 point road favorite and the total is currently 50.5. Be sure to check out our free NFL picks for more NFL predictions throughout the season.

San Francisco in control of the NFC West

The San Francisco 49ers are one of three remaining undefeated teams in the NFL and are in search of their first Super Bowl title since 1994. The 49ers (6-0) have qualified for the playoffs in five of the last ten seasons and have nine playoffs victories during the span. On Monday, San Francisco built a 17-point halftime lead and held on late for a 23-17 home victory versus Washington. 

All-Pro RB Christian McCaffrey carried 16 times for 64 yards and found the end zone twice. San Francisco TE George Kittle caught five passes for 69 yards and a touchdown. Mike Evans added a game-high 94 receiving yards for the 49ers, who won despite committing 11 penalties for 88 yards. 

The 49ers rank ninth in the league in total offense (366.7 ypg) and are scoring a shade below 30 points per game. Fifth-year QB Brock Purdy is tied for first in the NFL with 14 touchdowns and a 83 QBR. San Francisco is currently fifth in the NFL in total defense (300 ypg) and is limiting the opposition to 18.3 points per contest.

Atlanta looking for their first home victory

The Atlanta Falcons are winless through their first three home games and are 1.5 games behind Carolina for the top spot in the NFC South Division. The Falcons (2-4) have not won the division title since their epic Super Bowl collapse almost a decade ago. On Sunday, Atlanta trailed by as many as 24 points during a 31-23 home loss versus Chicago. 

Atlanta TE Kyle Pitts Sr. caught two touchdown passes in the final ten minutes to make the final score look more respectable. Michael Penix Jr. threw for 225 yards and three scores. All-Pro RB Bijan Robinson added 61 rushing yards for the Falcons, who were outgained by a 368-257 margin. 

Atlanta is currently in the middle of the NFL in total offense (344.3 ypg) and averages 23.7 points per game. Bijan Robinson ranks second behind Kenneth Walker III with 641 rushing yards and four scores. The Falcons are fifth in the league in defensive pressure rate (35.1%) and are giving up 25.5 points per contest.

San Francisco 49ers vs Atlanta Falcons Picks and Prediction

Pick: Atlanta Falcons +3.5

San Francisco DE Nick Bosa has missed the last few weeks with a calf injury and will likely be held out until after the team’s week eight bye. The 49ers own a 48-32-1 record in this series and defeated the Falcons 20-10 in 2025. San Francisco is 4-2 ATS and covers by an average of 7.1 points. However, the 49ers have one less day to prepare and are flying across the country. Take the Falcons to cover.

Pick: Over 50.5

These two teams rank in the bottom eight of the NFL in seconds per play. Atlanta owns a 4-2 O/U record and their games are going over by an average of 4.1 points. The 49ers are the best team in red zone touchdown percentage (85%) and the Falcons are fifth in that category (75%). Take the over.

Final Score Prediction: Atlanta Falcons 30, San Francisco 49ers 27