San Francisco 49ers vs. LA Rams, Picks and Prediction, Thursday, October 2, 2025
Use Code SSWC Thursday night football features a matchup of NFC West sides and we’re breaking it all down for you, plus providing our 49ers vs. Rams predictions to get you ready. San Francisco (3-1 SU, 2-2 ATS) lost for the first time this season last week versus Jacksonville, 26-21, as -3.5 favorites at home. Los Angeles (3-1 SU, 3-1 ATS) got past Indianapolis last Sunday, 27-20, as -3.5 favorites at home. Kickoff from SoFi Stadium is scheduled for 8:15 EST and this is just the start of the NFL slate for the week, so be sure to check out all of our Free NFL Picks.
49ers lack enough offense to remain unbeaten
The 49ers opened the season with three straight wins before the offense came up short on Sunday versus Jacksonville. They found themselves down 17-6 at halftime and scored only 15 more points the rest of the way, falling shy in their comeback effort. San Francisco’s offense had 389 total yards and 22 first downs, while the defense allowed 325 yards and 18 first downs.
The Niners’ offense ranks fifth in the NFL with 368 total yards per game and 23rd with an average of 20 points per game. They have the second-best passing attack in the league with an average of 280 passing yards per game. Brock Purdy returned to the lineup after missing two weeks and went 22-39 for 309 yards, 2 TDs, and 2 INTs. With the short week and his toe injury, he’s listed as questionable for this matchup. Through two games, he’s thrown for 54 yards, 4 TDs and 4 INTs. Christian McCaffrey has been targeted 43 times in the passing game, making 31 catches for 305 yards and 2 TDs. He also leads the Niners with 225 of the team’s 352 rushing yards. McCaffrey ran for 49 yards against Jacksonville and has a high-water mark of 69 rushing yards in a game this season.
Defensively, the 49ers have allowed 18.8 points, seventh best in the league, and 280.5 total yards per game, sixth best in the NFL. They have had some issues versus the run, allowing 115.5 yards per game and four yards per carry. Against the pass, they rank sixth in the league, allowing 165 yards per game. They’ve been able to get to the opposing QB for five sacks, tied for fourth fewest, and they are one of only three teams without an interception. Linebacker Fred Warner leads the team and is tied for seventh in the league with 38 tackles to go with 5.5 stuffs and two forced fumbles. Nick Bosa and Bryce Huff each have two sacks.
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Injury report (with Monday’s practice availability)
- DL Robert Beat Jr. (ankle) DNP
- CB Renardo Green (neck) limited
- DL Yetur Gross-Matos (knee) DNP
- WR Jauan Jennings (ankle, rib) DNP
- QB Mac Jones (knee) full
- OL Colton McKivitz (calf) full
- WR Ricky Pearsall (knee) DNP
- QB Brock Purdy (toe) DNP
- WR Jordan Watkins (calf) DNP
- DL CJ West (thumb) DNP
- DL Mykel Williams (wrist, oblique) limited
- LB Dee Winters (knee) limited
Rams get right back on track
The Rams had a nice bounce-back win following their lone loss of the season. They were in control for much of the game against the Colts on Sunday, going into the half with a 13-10 lead and outscoring their opponent 14-10 in the fourth quarter. The offense picked up 24 first downs as part of their 425-yard day. On defense, Los Angeles kept Indianapolis to 333 yards and 17 first downs.
In terms of yardage, the Rams have the fourth-best offense in the NFL with 388.3 yards per game and their 25 points per game rank 13th overall. They rank third in the league with their passing attack, averaging 267.5 yards per game. Matthew Stafford went 29-41 for 375 yards and 3 TDs in Sunday’s win. The veteran QB ranks second in the league with 1,114 passing yards, averaging 8.2 yards per completion with 8 TDs and 2 INTs.  Puka Nacua tops the NFL with 42 receptions and 503 receiving yards. He’s found the end zone once. The Rams are 13th in the league in rushing with 120.8 yards per game. Kyren Williams ranks seventh in the league with 303 rushing yards and has also found the end zone once.
On defense, Los Angeles is giving up 20.3 points, 10th best in the NFL, and 284.5 total yards per game, ninth in the league. Versus the rush, their opponents average 3.9 yards per carry and 98.5 yards per game against them. Versus the pass, the Rams are giving up 186 yards per game. They are tied for second in the league with 14 sacks and they’ve picked off three passes. Kam Curl tops the team with 35 tackles and two interceptions, and he’s also picked up a sack, two tackles for loss and three pass deflections. Byron Young leads the team and is tied for the league lead with five sacks.
Injury report (with Monday’s practice availability)
- TE Tyler Higbee (hip) DNP
- OT Rob Havenstein (ankle) DNP
- G Steve Avila (ankle) full
- TE Colby Parkinson (shoulder) full
- S Kamren Kinchens (shoulder) limited
49ers vs. Rams predictions
Spread Pick for 49ers vs. Rams
- Los Angeles -5.5 (5 units)
Last season’s series between the division rivals was swept by the Rams, who were 2-0 SU and ATS. The Niners are still banged up and with the short week, that will be an issue. Purdy just got back into the lineup after a toe injury sidelined him for two weeks, so having only three recovery days will surely slow the San Fran QB in this matchup. The Rams' defense puts a ton of pressure in the backfield, which is going to make it a long day for Purdy. Los Angeles has been able to establish both sides of their offense this season, so they’ll be okay should something be taken from them. The Stafford-Nacua connection has been the best in the league this season. Stafford is going to have tons of time to work in the pocket, so I would expect many more connections between the Rams duo. Los Angeles is 3-1 SU and 4-0 ATS in their last four games against the Niners.
Take the Rams to cover.
Over/Under for 49ers vs. Rams
- Over 47 (5 units)
When these two last met, they combined for 18 points in a game that hit well under against a 48.5-point total. Offense for both sides has had its moments thus far. The Niners found ways to pick up wins without their starting QB in the mix, but they now have him back, so we should expect them to start moving the ball more effectively as the weeks go on. Los Angeles has one of the most veteran field generals in the league, leading them, so they are apt to bust out at any time. Following their 14-point effort in the season opener, the Rams have scored at least 26 points in their next three games. The Niners scored 21 points or more in two of four games. The over is 4-1 in the last five meetings between the teams.
Take the over.
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