San Francisco 49ers vs Seattle Seahawks Picks and Predictions for Sunday, October 11, 2026

The San Francisco 49ers visit the Seattle Seahawks on Sunday at Lumen Field, with the opening kickoff set for 4:25 PM ET on Fox. San Francisco lead the NFC West at 4-0 after defeating Denver 24-14. Seattle are second in the division at 3-1 following a 30-23 victory over the Los Angeles Chargers. The 49ers have won all four games, while Seattle have won three of four. The Seahawks are three-point home favorites, with the total at 45.5. This marks their first meeting since last season's playoff matchup. Cash in a winning ticket with our free NFL picks.

San Francisco 49ers Defending Their Perfect Record

San Francisco have opened the season with four consecutive victories, defeating the Los Angeles Rams 27-7, Miami 35-13, Arizona 36-30, and Denver 24-14. Brock Purdy has completed 69.9% of his passes for 251.8 yards per game, 11 touchdowns and one interception. George Kittle leads the receiving attack with 16 catches, 244 yards, and four touchdowns. Mike Evans has added 213 receiving yards and two scores, while Deebo Samuel has contributed 185 yards and three touchdowns. San Francisco has scored at least 24 points in every game.

The 49ers average 251.8 passing yards and 137.3 rushing yards per game, with 16 offensive touchdowns. Christian McCaffrey leads the ground attack with 218 yards and four touchdowns, while Purdy has added 122 rushing yards and one score. San Francisco averages 30.5 points while allowing just 16.0 per contest. The defense has recorded six sacks and one interception, with Keion White contributing two sacks. Fred Warner leads the team with 40 tackles. San Francisco has limited three opponents to 14 points or fewer, combining strong scoring production with consistent defensive results.

Injuries: Mike Evans (questionable), Upton Stout (questionable), James Thompson Jr. (doubtful), Marques Sigle (out), Kyle Juszczyk (out).

Seattle Seahawks Protecting Their Home Record

Seattle have won three of their opening four games, defeating New England 13-10, Arizona 31-7 and the Los Angeles Chargers 30-23. Their only defeat came against Washington, 33-31. The Seahawks are unbeaten in two home appearances and have scored at least 30 points in their last three games. Sam Darnold has completed 65.2% of his passes for 186.7 yards per appearance, six touchdowns and three interceptions. Drew Lock has also contributed four touchdown passes without an interception. Jaxon Smith-Njigba leads Seattle with 32 receptions, 481 yards and six touchdowns.

The Seahawks average 249.0 passing yards and 110.3 rushing yards per game, with 13 offensive touchdowns. Emanuel Wilson leads Seattle with 190 rushing yards and one touchdown, while Jadarian Price has added 119 yards. Seattle averages 26.3 points while allowing 18.3 per game. The defense has recorded 11 sacks and six interceptions, with Leonard Williams contributing three sacks. Ernest Jones IV leads the team with 41 tackles, while Julian Love has recorded two interceptions. Seattle has held two opponents to 10 points or fewer, although their last two games featured substantial scoring.

Injuries: Julian Neal (questionable), Leonard Williams (questionable), George Holani (questionable), Nehemiah Pritchett (questionable), Irv Charles (injured reserve, return designation).

Key to the Game

San Francisco's balanced offense faces a Seattle defense that has recorded 11 sacks and six interceptions. Purdy has thrown 11 touchdowns against one interception without being sacked, making protection a major matchup. Seattle's offense relies heavily on Smith-Njigba, who averages 120.3 receiving yards and has scored six touchdowns. San Francisco allows just 16.0 points per game, while Seattle is allowing 18.3. Both clubs have produced strong defensive results, but recent offensive performances suggest scoring chances will be available if quarterbacks avoid turnovers.

San Francisco 49ers vs Seattle Seahawks Game Pick

• San Francisco 49ers +3 (-110)

San Francisco has won four straight games, outscoring opponents 122-64 through the opening month. Purdy has thrown 11 touchdowns with only one interception, while McCaffrey has helped the 49ers average 137.3 rushing yards per game. Seattle has impressed defensively, but the Seahawks surrendered 33 points against Washington and 23 against the Chargers. San Francisco's ability to produce through both passing and rushing attacks creates problems for Seattle's defense and will help the 49ers cover the field goal spread. 

San Francisco 49ers vs Seattle Seahawks Over/Under Pick

• over 45.5 (-115)

Recent offensive production makes over 45.5 points attractive in this NFC West matchup. San Francisco averages 30.5 points per game, scoring at least 24 in every outing. Seattle has reached 30 points in three consecutive contests, with their last two games producing 64 and 53 combined points. Purdy's 11 touchdown passes and Smith-Njigba's six receiving scores highlight the attacking threats on both teams. Although both defenses have respectable season averages, the recent scoring trends create a strong case for a total above 45 points on Sunday.