Seattle Seahawks vs Arizona Cardinals Picks and Prediction for Sunday September 20 2026

The Seattle Seahawks visit the Arizona Cardinals at State Farm Stadium in Glendale, Arizona, on Sunday, September 20, 2026. Kickoff is scheduled for 4:25 PM ET. Both NFC West teams enter Week 2 at 1-0. Seattle opened its season with a victory, while Arizona went on the road and defeated the Los Angeles Chargers 26-14. The Seahawks are currently around 4.5-point road favorites, with Arizona at +4.5 and the total set around 41.5 points.

Seattle Faces a Much Different Test

Seattle enters Week 2 undefeated, but this divisional matchup should present a significantly different challenge. The Seahawks have the opportunity to start 2-0 and earn an important road victory inside the NFC West.

The biggest question is how effectively Seattle can create offensive consistency against an Arizona team that controlled large portions of its opener. Divisional road games are rarely ideal spots to lay multiple points, particularly against an opponent that also enters with momentum.

Seattle's defense will be important because Arizona demonstrated an ability to control possession in Week 1. If the Seahawks can create negative plays and force the Cardinals into difficult third-down situations, Seattle should have enough opportunities offensively to win.

Arizona's Week 1 Formula Can Travel Home

Arizona's 26-14 victory over the Chargers was impressive because the Cardinals went on the road and controlled the game. Arizona possessed the football for more than 37 minutes, limiting Los Angeles' opportunities and keeping its defense fresh.

That possession advantage provides a blueprint against Seattle. Arizona doesn't need to produce explosive scores every few minutes if it can consistently sustain drives and shorten the game. That approach becomes particularly valuable when catching more than a field goal at home.

The Cardinals also held the Chargers to only 14 points. If Arizona can combine another strong defensive performance with its possession-heavy offensive approach, Seattle may have difficulty creating enough separation to cover 4.5 points.

Seattle Seahawks vs Arizona Cardinals Picks and Prediction

Pick: Arizona Cardinals +4.5

Take the Arizona Cardinals +4.5. Both teams are 1-0, Arizona is at home and the Cardinals just produced an impressive 26-14 road victory. Arizona's ability to control possession gives it an excellent formula for keeping a divisional matchup close. Seattle may still win, but asking the Seahawks to cover more than a field goal on the road is aggressive.

Pick: Under 41.5

Take the Under 41.5. Arizona held Los Angeles to 14 points and controlled possession for more than 37 minutes in Week 1. That style reduces possessions and limits opportunities for both offenses. Seattle's best route to victory also doesn't require turning this into a shootout. A projected final around Seattle 21, Arizona 20 gives us the Cardinals cover while remaining below the total.

Final Picks: Arizona Cardinals +4.5 and Under 41.5