Seattle Seahawks vs. Arizona Cardinals Picks and Prediction - Thursday, September 25, 2025
It’s an NFC West clash on Thursday night and we’re getting your ready with our Seahawks vs. Cardinals predictions. Seattle (2-1 SU, 2-1 ATS) smoked the Saints last week, 44-13, as -7.5 favorites at home. Arizona (2-1 SU, 2-1 ATS) fell just shy of remaining undefeated, losing 16-15 to San Francisco as +2 underdogs on the road on Sunday. Kickoff from State Farm Stadium in Glendale is scheduled for 8:15 EST and for the rest of the week’s action, check out our award-winning NFL Predictions.
Seahawks offense gets teams back on track
After losing their season opener by five points, the Seahawks won back-to-back games by an average of 22.5 points per. The offense exploded out of the gate on Sunday, scoring 21 first-quarter points and giving the team a 38-6 halftime lead. They had 320 total yards and 22 first downs in the win. Seattle’s defense kept the Saints to 284 total yards and only allowed them to cross the goal line late in the game.
Seattle is averaging 29.3 points and 315 total yards per game. They’ve been a bit better in the passing game, averaging 219 yards per game. Sam Darnold was crisp on Sunday, going 14-18 for 218 yards and two touchdowns. He’s completed 70.3% of his passes this year for 663 yards, 4 TDs, and two interceptions. The offensive line has allowed only three sacks against him. Jaxon Smith-Njigba is fifth in the league with 22 catches and second with 323 receiving yards. The Seahawks have handed the ball off 88 times for 288 yards, and their 3.3 yards per carry is fourth-worst in the league. Kenneth Walker III has received nearly half of the workload, taking 39 carries for 163 yards and three touchdowns.
The Seahawks' scoring defense ranks second in the league after three games, allowing 15.7 points per game. They’ve given up 311.7 total yards per game. Against the run, they rank seventh, allowing 90 yards per game while opponents average 3.2 yards per carry against them. Against the pass, they are giving up 221.7 yards per game, 13th in the NFL. They are second in the league with five interceptions to go with six sacks. Derion Kendrick has come down with two of those interceptions while also defending a team-high five passes. Byron Murphy II has 2.5 sacks out of his 14 tackles.
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Injury report (with Monday’s practice availability)
- TE Elijah Arroyo (groin) limited
- S Nick Emmanwori (ankle) limited
- G/T Josh Jones (ankle) DNP
- S Julian Love (hamstring) limited
- LB Boye Mafe (toe) limited
- FB Robbie Ouzts (ankle) DNP
- C Jalen Sundell (ankle, elbow) limited
- DE Leonard Williams (elbow, shoulder) limited
- CB Devon Witherspoon (knee) limited
Cardinals come up short
All of the Cardinals’ games thus far have been decided by a score or less, and last week, it was just a point that knocked them from the ranks of the unbeaten. The offense failed to move the ball, and the team had just two field goals through three quarters before the defense allowed San Francisco to score the game-winning kick as time expired. The offense finished the day with only 260 yards and 16 first downs, while the defense yielded 355 yards in the loss.
Arizona’s offense is averaging 20.7 points and 276.3 total yards per game. They’ve gone for 165 yards per game via the pass. Kyler Murray went 22-35 and threw for only 159 yards in Sunday’s loss. The Cardinals’ QB has completed 67.4% of his passes for 542 yards and four touchdowns, with one interception. He has also run for 107 yards on 20 carries. Murray’s top target has been tight end Trey McBride, who has caught 17 of the 24 passes thrown in his direction for 182 yards and a TD. Arizona has rushed the ball 77 times for 334 yards, averaging 4.3 yards per carry. Trey Benson got a season-high 10 carries against San Francisco on Sunday. He leads the team with 125 rushing yards and averages six yards per carry.
The Cardinals rank fifth in scoring defense, allowing 17 points per game, but are 23rd with 340.7 total yards allowed per game. They’ve fared very well against the run, allowing only 76.3 yards per game, the fourth best mark in the league. However, they have one of the worst passing defenses, allowing 264.3 yards per game, third most in the league. They’ve been able to get some pressure up front with five sacks and they’ve picked off two passes. Mack Wilson Sr. leads the team and ranks 10th in the league with 28 tackles. Calais Campbell and Josh Sweat each have two sacks.
Injury report (with Monday’s practice availability)
- OT Kelvin Beachum (knee, NIR-rest) DNP
- RB James Conner (foot) DNP
- CB Will Johnson (groin) DNP
- WR Zay Jones (concussion) DNP
- G Evan Brown (ankle) limited
- LB Akeen Davis-Gaither (elbow) limited
- CB Darren Hall (ankle) limited
- G Will Hernandez (knee) limited
- OT Paris Johnson Jr. (knee) limited
Seahawks vs. Cardinals Picks
Spread Pick for Seahawks vs. Cardinals
- Seattle +1.5 (5 units)
The Seahawks went 2-0 SU and ATS in the season series between these two last year. Despite identical records, these two teams have looked different getting to that point. The Cardinals were not particularly dominant in their two wins, and they were quite shaky in their loss to San Francisco, who was using their backup QB. Arizona has struggled with its offense, and Murray has not had the space he needs to make things happen. Seattle also had their struggles versus the 49ers in their season opener, but it has since looked really good. Darnold continues to move the team into position to score, and they’ve taken advantage, unlike the Cardinals. Seattle’s defensive front should be able to get through the thin Cardinals line and apply pressure in the backfield. Seattle is 8-2 SU and 6-3-1 ATS in their last ten games against Arizona.
Take the Seahawks to cover.
Over/Under Pick for Seahawks vs. Cardinals
- Over 43.5 (4 units)
Last season, the two games between these teams split against the total, 1-1, and they averaged a combined 35 points per game. The Seahawks offense came out a little slow but has since picked up the pace. Darnold and Smith-Njigba are forming a very strong bond, which is allowing the pass game to open things up for the offense. The Cardinals offer up one of the worst passing defenses in the league, so I’m expecting Seattle to light things up once again, especially with the spotlight on. The Cardinals' offense might be an issue. Can we rely on them to add enough to the mix? If they can get a running game established, they’ll be in better shape and Murray will be allowed more time. I like for them to take better advantage of field position in this game and if they give us three scores, we’ll be in fine shape. Seattle’s offense is doing enough to cover the difference.
Take the over.
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