Seattle Seahawks vs. Los Angeles Rams Prediction and Picks for Sunday, November 16th, 2025
Sunday’s NFL slate features plenty of exciting matchups, but this NFC West showdown between the Seattle Seahawks (7-2) and the Los Angeles Rams (7-2) is the marquee matchup. We’ve got you covered with our Seahawks vs. Rams prediction. Kickoff is scheduled for 4:05 ET from SoFi Stadium in Inglewood, CA. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Seahawks Win Fourth Straight Game
The Seattle Seahawks are in the second year of the Mike Macdonald era, and the defensive guru has this team firing on all cylinders. They’re off to a 7-2 start, which includes their recent four-game winning streak against the Jaguars (20-12), Texans (27-19), Commanders (38-14), and Cardinals (44-22). Seattle currently holds the second seed in the NFC. They’re priced to +135 to win the NFC West, while sitting at +950 to win the Super Bowl. From a game-by-game betting angle, the Seahawks are 7-2 ATS, and they’ve seen six of their nine games go over the total.
In terms of personnel, it’s first-year Seattle QB Sam Darnold leading the offense this year. He has thrown for 2,262 yards on a 71.1% completion rate, adding 17 touchdowns and six interceptions. WR Jaxon Smith-Njigba has emerged as his favorite target, hauling in 63 passes for 1,041 yards and five touchdowns. RB Kenneth Walker III has spearheaded the rushing attack, gaining 539 yards and three touchdowns on 120 carries (4.5 YPC).
- Offensively, the Seahawks are scoring 30.6 points per game (third), while averaging 360.4 yards per week (ninth).
- Defensively, they are sixth in the NFL this year, conceding 19.1 points per game. They’re allowing 307.3 yards per contest, which is ninth.
- Injury Report: As of Friday’s injury report, WR Tory Horton (groin, shin) and C Jalen Sundell (knee) have both been ruled out. WR Cooper Kupp (hamstring, wrist) and S Coby Bryant (personal) have an “unspecified” status, but they both practiced in full on Friday.
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Rams Cruise Past the Niners
Meanwhile, the Los Angeles Rams are looking like a force again under Coach Sean McVay, who’s now in his ninth season as the head coach. The Rams are 7-2, and they currently possess the top wild-card spot in the NFC. They’re tied atop the NFC West and are priced at -125 to win the division. Los Angeles owns the second-shortest odds (+650) to win the Super Bowl. The Rams have gone 7-2 ATS this season and they’ve seen five of their nine games go under the total. They enter this marquee clash riding a four-game winning streak, where they’ve taken care of the Ravens (17-3), Jaguars (35-7), Saints (34-10), and 49ers (42-26), most recently.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Marc David | +521.00 |
| 2 |  Rob Vincilleti | +502.00 |
| 3 |  Bruce Marshall | +471.00 |
| 4 |  Patty Reyes | +400.00 |
| 5 |  Mike Lundin | +288.00 |
It’s veteran quarterback Matthew Stafford leading the charge once again this season. The signal caller has amassed 2,427 yards on a 67.1% completion rate, adding 25 touchdowns and only two interceptions. WR Puka Nacua (775 yards, 4 TD) and Davante Adams (568 yards, 9 TD) are the lead targets in the passing attack. RB Kyren Williams has led the ground game, adding 659 yards and five touchdowns.
- Los Angeles’ offense has been elite this season, ranking fifth in scoring (27.9 PPF), while putting up 373.3 yards per game (fifth).
- On the defensive side, the Rams are second this season, allowing 17.0 points per game. In terms of yardage, they’re 11th, conceding 312.9 yards per contest.
- Injury Report: DE Kobie Turner (back) didn’t practice on Thursday, while WR Davante Adams (oblique) was limited.
Seahawks vs. Rams Pick
Spread Pick for Seahawks vs. Rams
- Los Angeles Rams -3.0 (-110) (5 units)
Both of these teams are firing on all cylinders, and they each enter the game riding four-game winning streaks. So, this number of LAR -3.0 is fair and accurate when considering each team’s recent form and overall success, while adding in 3.0 points for the location. With all of that being said, I’m riding with the Rams -3.0 at home. I think the home-field advantage will be a big factor in this one, as Los Angeles is 4-1 ATS in its last five home games against Seattle.
Also, I’m just not sure that I can trust Sam Darnold in such a marquee spot. He has failed to deliver under the bright lights throughout his career, and he’s becoming a guy that I fade in these types of moments. It’s worth noting that the Seahawks also have the 22nd-ranked strength of schedule, so once again, we’ll see how they fare against a top-tier opponent. I’ll take the Rams to win and cover this game.
Over/Under Pick for Seahawks vs. Rams
- Over 48.5 (-110) (5 units)
I’ll take the over as well. These are two top-five offenses, each scoring more than 27.5 points per game this season. With all of the offensive star power on the field, combined with Matthew Stafford playing at such a high level, I think we’ll see this game go over the total. My best guess would be a 27-24 win for Los Angeles.
Both of these teams have been decimating their opposition recently, winning each of their last four games by 8+ points. During their respective four-game winning streaks, the Seahawks are averaging 32.3 PPG, while the Rams are scoring 32 PPG. The over is 4-1 in Seattle’s last five games, and that’s a trend that I expect to continue on Sunday afternoon.
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