Tennessee Titans vs Denver Broncos Pick and Prediction September 7th, 2025
In week one of the NFL season, the Broncos will host the Tennessee Titans on Sunday at 4:05 p.m. EST in Mile High Stadium. Check out our Tennessee Titans vs Denver Broncos pick and prediction here!
Tennessee had the worst record in the NFL last season and is looking to start the new season strong with a win under #1 pick Cam Ward. Meanwhile, Denver had a surprise entrance into the playoffs with rookie QB Bo Nix. This will be the year to determine if Nix will continue to progress or if he will have a sophomore slump. Denver is favored by 9.5 points while the total is set at 41.5 points. Can the Titans provide an upset win on the road?
Titans Trying Again with Cam
Tennessee was not at their optimal position on the offensive end. Will Levis was the primary QB last year with a 63.1% completion percentage for 2,091 yards, 13 touchdowns, and 12 interceptions. Mason Rudolph handled a sizable chunk of reps as well due to Levis's injuries and ineffectiveness. Rudolph completed 64% of his passes for 1,530 yards, 9 touchdowns, and 9 interceptions in eight games. Tony Pollard was the leading rusher with 1,079 yards and five touchdowns on 260 carries. Calvin Ridley was far and away the #1 receiver on the team with 1,017 yards and 64 receptions, but Nick Westbrook-Ikhine had the majority of TD receptions with nine. As a unit, Tennessee ranked 26th in yards/game, 26th in passing, and 20th in rushing. They also only managed 18.3 points per game, good for 27th in the league.
On defense, Kenneth Murray Jr. led the squad in tackles with 95 and including 57 solo tackles and 38 tackle assists. He also had 3.5 sacks, but Harold Landry III had nine sacks to lead the unit. Amani Hooker and Jarvis Brownlee Jr. had the most passes defended with nine each and Hooker was the only one with multiple interceptions on the team. He had five to put it in perspective. As a collective, the Tennessee defense ranked 2nd in yards/game, 2nd in passing defense, but 26th against the run. Their 27.1 points per game given up on average ranks 30th in the league. There are some positives on the defensive end, but a lot of negatives that need to be fixed for their season to be a success this year.
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Broncos Believing in Bo
Denver was rejuvenated after the Russell Wilson saga proved to be a nightmare. Enter Bo Nix, who completed 66.3% of his passes for 3,775 yards, 29 touchdowns, and 12 interceptions as a rookie. Nix delivered the Broncos to a playoff spot, which is all Denver fans could ask for. Javonte Williams was the leading back with 513 yards on 139 carries, but Jaleel McLaughlin was not far behind with 496 yards on 113 carries. Nix tied with Williams for the lead in touchdowns with four each. Courtland Sutton moved to the #1 wideout after the departure of Jerry Jeudy and earned 81 receptions along with 1,081 yards and eight touchdowns to lead the team. Marvin Mims Jr. was also productive as a red zone target with six TD receptions of his own. While Denver ranked in the bottom half in yards/game, passing yards/game, and 16th in rushing yards per game, they were still a top-ten team in scoring with an average of 25 points per game. Denver is hoping another year under Nix's belt might help him improve even more this upcoming season.
The defense is where Denver really shines, as they ranked 7th in yards per game, 19th against the pass, and 3rd against the run. Their 18.3 points surrendered per game on average ranked 3rd among all teams last season. The Broncos expect their defense to be a force again this season, and nobody is really doubting them. Brandon Jones led the Broncos with 115 total tackles last season while Cody Barton had the most tackle assists with 53. He was the only other player to reach 100+ tackles in a year for the Broncos. Nik Bonnitto had a team-high 13.5 sacks, but Jonathon Cooper followed behind with 10.5 of his own. Zach Allen also had 8.5 sacks to make the pash rush one of the best. Pat Surtain II was the leading corner for the Broncos with 11 passes defended, while Brandon Jones and Ja'Quan McMillian had ten each. Surtain II also led the team with four interceptions. If the Broncos can bring back their elite defense, they should make the wild card again at the very least.
Titans vs. Broncos Pick
Spread Pick for Titans vs. Broncos
- Broncos -9.5
Tennessee may keep things interesting to start the game, but the Broncos should prevail convincingly here. Cam Ward will be making his first start in the NFL and while he may have the talent, he will get a fresh wave of experience against one of the best defenses in the NFL. The effects of Mile High Stadium will be tricky for Tennessee as well, providing a huge advantage for the Broncos. We have to remember that Tennessee was one of the worst teams in the league last year and the Broncos were a playoff caliber team. While having Cam Ward helps, the Broncos have all the advantages from top to bottom to win here.
Over/Under Pick for Titans vs. Broncos
- Under 41.5
This one is a bit tricky, but ultimately, I decided to put more of my faith in Denver's defense. Considering they averaged less than 20 points per game on defense last season, I expect them to be around that mark or better against a Tennessee team that doesn't have any elite-level talent on the offensive side of the ball. Cam Ward will be adjusting to the NFL and that will take games and reps for him to figure out the difference between college and pro football. I expect Denver to gain a sizable lead and run the ball down Tennessee's throat, quickly removing time off the clock. I don't expect Tennessee to score more than 17 points, and Denver doesn't need to do much on offense to win this game, so the offense does not need to be at full throttle in this one.
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