Titans vs. Colts, Preview, Odds, Prediction and Picks, Sunday, October 26th, 2025
Use Code SSWC The NFL season churns ahead, and we have an exciting divisional matchup on Sunday’s slate, as the Tennessee Titans (1-6) take on the Indianapolis Colts (6-1). We’ve got you covered with our Titans vs. Colts prediction. Kickoff is scheduled for 4:25 ET from Lucas Oil Stadium in Indianapolis, IN. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Titans Slide To 1-6
The expectations weren’t too high entering the season for the Tennessee Titans, but this season has turned into a complete disaster for the organization. They fired Coach Brian Callahan after a 1-5 start to the campaign, which made way for interim coach Mike McCoy to take the reins of the squad. The Titans are 0-1 under his control, and the team has lost two straight games overall to the Raiders (20-10) and the Patriots (31-13), more recently. From a sports betting perspective, Tennessee enters the weekend at 2-5 ATS and they’ve seen four of their seven games go over the total.
In terms of personnel, it’s number one overall pick Cam Ward handling the quarterbacking responsibilities this year. Ward hasn’t looked great, throwing for 1,356 yards on a 57.6% completion rate, adding four touchdowns and five picks. Out wide, Calvin Ridley (290 yards) has been his top target, but the WR will miss this weekend. WR Elic Ayomanor (225 yards, 2 TD) and TE Chig Okonkwo (218 yards) will look to pick up the slack in the receiving game. RB Tony Pollard has spearheaded the rushing attack, gaining 380 yards and two touchdowns on 98 carries (3.9 YPC).
- Tennessee’s offense has been awful this season, ranking last in scoring (13.7 PPG), while putting up 235.6 yards per game (32nd).
- On the defensive side, the Titans are 28th this season, allowing 27.4 points per game. In terms of yardage, they’re 24th, conceding 349.6 yards per contest.
- Injury Report: The following four players are confirmed out for Sunday’s game: OL Blake Hance (shoulder/back), WR Bryce Oliver (knee), WR Calvin Ridley (hamstring), and DT Jeffery Simmons (hamstring).
Colts Sit Atop the NFL at 6-1
Meanwhile, the vibes couldn’t be higher for the Indianapolis Colts this season, as they enter the weekend with the league’s best record of 6-1. Their lone loss was that 27-20 defeat in L.A. against the Rams, in which they coughed up the game late. Since then, the Colts have rattled off three straight wins over the Raiders (40-6), Cardinals (31-27), and Chargers (38-24), most recently. The sports betting market still isn’t completely sold on Indy, as they’re priced at +1200 to win the Super Bowl. As for the game-by-game betting numbers, the Colts are 5-2 ATS and 4-3 to the over in 2025.
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Newcomer Daniel Jones is the man under center this season, and he is putting together a nice campaign. The veteran quarterback has thrown for 1,790 yards on a 71.0% completion rate, adding 10 touchdowns and three picks. First-round draft pick TE Tyler Warren is the main target in the passing game with 439 yards and three touchdowns on 33 receptions. RB Jonathan Taylor continues to be a workhorse in the rushing attack, gaining 697 yards and 10 touchdowns on 131 totes (5.3 YPC).
- Offensively, the Colts are scoring 33.1 points per game (first), while averaging 380.3 yards per week (second).
- Defensively, they are eighth in the NFL this year, conceding 20.0 points per game. They’re allowing 345.7 yards per contest, which is 22nd.
- Injury Report: Both DE Samson Ebukam (knee) and CB Jaylon Jones (hamstring) are confirmed out for Sunday’s game.
Titans vs. Colts Pick
Spread Pick for Titans vs. Colts
- Indianapolis Colts -14.5 (-105) (5 units)
I’m always a bit hesitant to lay this many points in a professional football game, but I do think it’s a warranted line considering we have the best team in the league squaring off against the worst. Additionally, we’ve seen the Colts run up the score on lousy teams this season, notching big wins over the Dolphins (33-8), Titans (41-20), and Raiders (40-6) so far. I expect to see Indy lay it on Tennessee for a second time this year.
This has really been a spectacular run from the Colts. They have an average margin of victory of +13.1 points, and to put that into perspective, the next-closest team is the Lions (+9.1) at 4.0 points away. They take care of the ball, ranking third in turnover margin per game (+1.0). Tennessee is 23rd (-0.4) in that category. The Titans are also just 3-17 ATS in their last 20 games. With WR Calvin Ridley (hamstring) out, I don’t see how Tennessee keeps this game close.
Over/Under Pick for Titans vs. Colts
- Over 48.0 (-105) (5 units)
This is a tough total considering the disparity between the teams, but I do think it’s best to play the over. For starters, we saw these teams combine for 61 points earlier this season. With the way the Colts are firing offensively, there’s a good chance they drop another 40-point performance by themselves. They lead the league in scoring (33.1 PPG) and have put up 38+ points in three of their seven games this year.
Meanwhile, Indy’s defense hasn’t been flawless, giving up 20.0 points per game (eighth). That seems like a high threshold for this horrid Tennessee offense to hit, but I do think they can manage to contribute around 13 points. The over is 4-2 in their last six games, while going 7-3 in Indianapolis’ last 10 contests. Give me the over.
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