TNF Seattle vs Arizona Props - Free NFL Prop Bets

By: Dean Whitaker Published 09/25/2025, 02:20 PM ET
Kyler Murray looks to lead the Cardinals over the Seahawks
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Week 4 Thursday Night Football brings a key NFC West clash as the Seattle Seahawks square off with the Arizona Cardinals. This divisional showdown offers plenty of betting potential, and we’ve locked in three of the best prop bets for tonight. Each selection is powered by matchup data, recent trends, and player usage, giving bettors a sharp edge. Start the week under the lights with a primetime opportunity to cash in.

TNF Prop Best Bet #1: Seattle Over 23.5 Points Scored

Seattle is well-positioned to clear the 23.5-point mark tonight against an Arizona defense that’s struggled to contain explosive plays and red zone efficiency. The Seahawks have scored 75 points over their last two games and are averaging 26.8 points per game on the season. Sam Darnold has found rhythm with Jaxon Smith-Njigba and DK Metcalf, while Kenneth Walker’s downhill running keeps defenses honest and opens up play-action opportunities. Arizona ranks bottom-10 in opponent scoring and has allowed 24+ points in five of its last six games.

With Seattle’s offensive line improving and the Cardinals’ secondary dealing with injuries, expect the Seahawks to push tempo and capitalize on mismatches. Darnold’s deep ball has been sharp, and Seattle has converted over 60% of its red zone trips into touchdowns over the past month. Whether through explosive strikes or sustained drives, the Seahawks have multiple paths to a 27–30 point finish. This prop aligns with both recent form and matchup vulnerability.

Also see: Seattle vs Arizona prediction

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TNF Prop Best Bet #2: Kyler Murray 25+ Yards Rushing

Kyler Murray is a strong candidate to eclipse 25 rushing yards tonight, given his dual-threat profile and the matchup against Seattle’s aggressive front. Murray has cleared that mark in four of his last five starts and remains one of the league’s most elusive quarterbacks when plays break down. Seattle’s defense ranks top-10 in pressure rate but has struggled to contain mobile QBs, allowing 30+ rushing yards to both Jalen Hurts and Justin Fields earlier this season.

With Arizona likely playing from behind and Murray extending drives with his legs, designed runs and scrambles should be part of the game plan. He’s averaging 5.8 yards per carry and has logged multiple rushes of 10+ yards in recent weeks. If Seattle collapses the pocket without disciplined edge containment, Murray could rack up yardage quickly. Expect 6–8 carries and a finish in the 35–45 yard range, making Over 25 a sharp play.

TNF Prop Best Bet #3: Jaxon Smith-Njigba 80+ Yards Receing

Jaxon Smith-Njigba is trending toward a breakout performance, and 80+ receiving yards is well within reach tonight against Arizona’s vulnerable secondary. He’s seen a steady uptick in targets and air yards over the past three games, and his chemistry with Sam Darnold has been immediate—averaging over 17 yards per catch since Darnold took over. Arizona ranks bottom-10 in explosive pass plays allowed and has struggled to contain slot receivers, which is where JSN does most of his damage.

With DK Metcalf drawing top coverage and Kenneth Walker keeping linebackers honest, Smith-Njigba should find plenty of space in the intermediate zones and seam routes. Seattle’s offense has leaned into tempo and vertical shots, and JSN has logged multiple catches of 20+ yards in recent weeks. If game flow stays competitive and Seattle maintains its aggressive script, expect 6–8 targets and a finish in the 85–100 yard range. This prop has both matchup and momentum on its side.

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Recapping Today TNF Prop Best Bets

  • Seattle Over 23.5 points Scored (+120)
  • Kyler Murray 25+ Yards Rushing (-155)
  • Jaxon Smith-Njigba 80+ Yards Receiving (-133)
Odds Are Courtesy Of DraftKings
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