Vegas Golden Knights vs. St. Louis Blues Picks and Prediction for Thursday October 22 2026
Vegas Golden Knights vs St. Louis Blues Game Information
The Vegas Golden Knights will head to St. Louis, Missouri, Thursday night for a Western Conference matchup against the St. Louis Blues at Enterprise Center. The game is scheduled for 8:00 PM ET. Vegas comes into Thursday as one of the league's tougher teams, 8-3 overall, after a four-goal loss to Tampa Bay in their last outing that ended a three-game winning streak. Saint Louis has been mediocre this season, 4-4-1 overall, and won three of their last five, including a one-goal win over Winnipeg in their last outing. Vegas comes into Thursday a -120 road favorite. The Blues are a +100, and the total is 6.5. Stay in the loop with our NHL Picks.
Vegas tries to stay hot
Offensively, Las Vegas is rolling this season, averaging 3.91 goals on 30.2 shots per game. Defensively, Vegas has allowed 2.73goals on exactly 25 shots per game, but they've given up 10 total goals across their last two losses. Jack Eichel is leading Las Vegas this season with 18 points and 13 assists. Mark Stone is second on the roster with 15 points, and he leads the team with eight goals. Mitch Marner is the third player on the team in double digits with 12 points this season.
Carter Hart was terrible in the net for Vegas in their last outing, giving up six goals on 21 shots to post a .714 save percentage in just over 59 minutes. Ivan Barbashev and Mark Stone provided the only spark for the Vegas offense, scoring one goal each.
Key Injury Report for Vegas:
- Parker Wotherspoon (IR) – Nov 8
St. Louis looks to lean on home fans
The Saint Louis offense has been solid this season, averaging 3.22goals and 26.2 shots. Defensively, St. Louis has been shaky, allowing 3.22 goals on 27.3 shots per game. Mason McTavish is leading Saint Louis this season with 9 points and five goals. Dylan Holloway is second on the roster with seven points along with the team-leading 6 assists. Jimmy Snuggerud, Pius Suter, Philip Broberg, and Connor McMichael are all tied for third on the team with six points each.
Joel Hofer did the work between the pipes for Saint Louis in their last outing, giving up one goal and 33 shots to post a .970 save percentage in the win. Phillip Broberg led the charge for the Saint Louis offense with one goal and one assist on six shots. Jimmy Snuggerud added to the offense with one goal in just under 20 minutes of game time.
Key Injury Report for St. Louis:
- Ross Johnston (IR) – Oct 2
- Torey King (IR-LT) – Jul 1
- Dillon Dube (IR) – Dec 4
- Alexey Toropchenko (IR) – Nov 14
- Tyler Tycker (IR) – Nov 12
Vegas Golden Knights vs St. Louis Blues Picks and Prediction
Pick: Vegas Golden Knights -120
Vegas has the offensive depth and experience necessary to make life difficult for St. Louis throughout Thursday night's matchup. The Golden Knights can generate pressure through their forecheck and force opponents into mistakes when attempting to clear the defensive zone. Jack Eichel gives Vegas a playmaker who can create scoring opportunities in several different situations, while Mark Stone provides another dangerous offensive option around the net. St. Louis will need to avoid turnovers in its own end and find ways to prevent Vegas from maintaining possession for extended periods. The Blues should have opportunities to respond offensively, but keeping up with the Golden Knights across four lines could become a problem. Vegas has enough weapons to take control of this matchup and leave St. Louis with a victory on the road.
Pick: Over 6.5
There should be opportunities for both teams to contribute offensively in this matchup, particularly if the game opens up after the first period. Vegas has several players capable of producing goals, and its ability to maintain pressure in the offensive zone could lead to quality chances around the net. St. Louis will need to generate its own scoring opportunities rather than spend most of the night defending against the Golden Knights. Robert Thomas can help the Blues create offense through his passing and ability to find teammates in dangerous positions. Both teams have the potential to capitalize on defensive mistakes, and special teams could become important if penalties begin to accumulate. Expect enough offensive production to push this matchup over the total.