San Francisco Giants vs. Arizona Diamondbacks Prediction and Picks - September 16, 2025
Giants vs. Diamondbacks Prediction and Picks - September 16, 2025
The Giants are facing off against the Diamondbacks in game two of their series at Chase Field in Phoenix, Arizona; keep reading for our Giants versus Diamondbacks prediction. San Francisco is fourth in the NL West with a record of 75-75. Arizona is third in the NL West with a record of 76-75. The Diamondbacks have a 6-5 record against the Giants this season. The first pitch is scheduled for 9:40 p.m. EDT. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
San Francisco Loses Key Game
The Giants are coming off a tough loss yesterday to the Diamondbacks with a final score of 8-1. This is the third loss in a row for the Giants as they continue on their road trip. San Francisco is two spots away from a wild card position but with their loss yesterday, they were overtaken by the Diamondbacks for the next team up for a wild card spot.
This season, the Giants have relied heavily on their pitching, ranking tenth overall in ERA at 3.86 and leading the league in home runs. However, this has not been enough to grab the wins needed to go to the playoffs as their hitting remains an issue. The Giants are 17th this season in runs and rank 26th in batting average at .237. In recent games, this batting has only gotten worse and as a result, has generated more losses than usual for the Giants.
At the time of writing this article, no pitcher has been confirmed for the Giants.
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Arizona Closing In On Wild Card
The Diamondbacks picked up a much-needed win yesterday against the Giants with a final score of 8-1. This is the third win in a row for the Diamondbacks and their fourth win in their last five games. The Diamondbacks have overtaken the Giants and now sit below the Mets for the bottom wild card spot in the National League.
Arizona has dominated the plate this season, ranking fourth in runs and 10th overall in batting average at .251. The Diamondbacks' slugging percentage of .435 (4th) has been crucial to their success this season, generating the sixth most home runs in the league. While their pitching has struggled this season, in recent game,s we have seen improvements to the Arizona mound, which has helped generate the wins needed to close in on a potential wild card position.
Left-handed pitcher Eduardo Rodriguez will be starting for the Diamondbacks on Tuesday.
Eduardo Rodriguez:
- has a record of 8-8 this season with an ERA of 4.98 and 130 strikeouts in his 26 starts.
- has a record of 2-1 with an ERA of 4.29 and 28 strikeouts in four starts against the Giants in his career.
Giants vs. Diamondbacks Prediction and Picks
Money Line Pick for Giants vs. Diamondbacks
- Diamondbacks Money Line (3 units)
The Diamondbacks have a record of 7-3 in their last ten games at home. The Giants have a record of 2-4 in their last six games against the Diamondbacks on the road. Arizona is now motivated as they overtake the Giants for a potential shot at a wild-card spot. While the Mets would have to lose a few games, the Diamondbacks can control their own future by grabbing as many wins as they can for the remainder of the month.
Over/Under Pick for Giants vs. Diamondbacks
- Over (4 units)
The Giants have an over/under record of 7-2-1 in their last ten games against the Diamondbacks. The Diamondbacks have an over/under record of 6-3-1 in their last ten games. Arizona is only capable of grabbing wins thanks to their hitting, even if its pitching has improved as of late. The Giants know they are not going to be able to find a win with their pitching alone and will have to face off against the Diamondbacks run for run if they want a chance to tie this series. We should expect a similar game to game one of this series, but with a little more help from the Giants should push us over the line.
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