St. Louis Cardinals vs. Milwaukee Brewers Prediction and Picks - September 14, 2025
The Milwaukee Brewers will close their series against the St. Louis Cardinals at American Family Field, and we have you ready to go with the Cardinals vs Brewers prediction.
Opening Pitch is slated for 2:10 PM Eastern, with the Brewers taking game one of the series. Read on for the Cardinals vs Brewers prediction and more free MLB picks.
This article was written before the completion of Saturday's action.
Cardinals Drop 4th Straight
St. Louis continues to struggle at the plate. Despite logging nine hits in game one, the Cardinals finished with only two runs as three batters finished with multiple hits at the plate. Alec Burleson led the way with two hits and an RBI as St. Louis struck out nine times in the contest. Andre Pallante got the start, and over five innings, he walked four and allowed four runs while failing to register a strikeout.
RHP Miles Mikolas is slated to start for the St. Louis Cardinals. This season, Mikolas has made 28 starts, posting a 7-10 record with a 4.84 ERA over 142.2 innings pitched. He has struck out 88 batters while issuing just 34 walks. Ball control continues to be a strength, but Mikolas has allowed three homers over his last five starts.
On the road this season, Mikolas holds the following splits:
- ERA: 3.86
- Opponent Batting Average (OBA): .261
- BB/K Ratio: 0.29
St. Louis enters this contest averaging 4.7 runs per contest, which lands them at 11th in the league. The Cardinals sit 3rd in the league in overall batting average. They have seen the ball a little weaker on the road this season, but more than half of their home runs and extra-base hits are coming away from home this season. St. Louis has hit their strongest under the lights this season, but they have struggled to drive home runners in scoring position. Fortunately, the Cardinals still sit in the top 10 in terms of hits per game. That being said, they do sit at the bottom 10 in home runs hit per game. St. Louis will look to lean on their ability to strike out at a low rate to find ways to drive runs home.
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Brewers Land Playoff Spot
Milwaukee ended its 3-game skid and clinched playoff birth as they scored eight runs on 11 hits. The Brewers finished with three batters logging multiple hits at the plate as the offense struck out just twice on the evening. Jackson Chourio led the way with two hits and two RBIs, and Christian Yelich added a home run in the 7th. Quinten Priester got the start, and over 5.1 innings, he struck out five and allowed two runs.
LHP José Quintana is set to make his next start for the Brewers. This season, Quintana has made 23 starts, compiling an 11-6 record with a 3.88 ERA across 127.2 innings pitched. The veteran left-hander has struck out 87 batters while issuing 48 walks, holding opposing hitters to a .240 batting average. That said, Quintana has allowed four home runs over his last four starts.
At home this season:
- ERA: 3.92
- Opponent Batting Average (OBA): .239
- BB/K Ratio: 0.43
Milwaukee enters this contest averaging 3.38 runs per game, which places them 24th in the league. The Brewers have struggled at the plate, currently sitting with a team batting average of .215, ranking 21st in the league. This offensive downturn is particularly evident at home, where they have faced challenges generating consistent run support. Night games have also posed difficulties, with the team’s batting average dipping below their overall season mark. Despite these struggles, Milwaukee has managed to record a total of 8 home runs, averaging one per game, indicating some power potential remains in the lineup. However, their on-base percentage stands at .277, reflecting ongoing issues with plate discipline and getting runners aboard. As the season progresses, the Brewers will need to address these offensive shortcomings to improve their standings in the highly competitive NL Central division.
Cardinals vs. Brewers Pick
Spread Pick For The Cardinals vs Brewers
- Milwaukee ML
Milwaukee continues to hit strongly at the plate this season, and they've remained patient at the plate. Meanwhile, the Cardinals have struggled with plate consistency, and strikeouts have been a thorn in their side, particularly when they are hitting on the road. Quintana has been solid on the mound this season, and he's struck out 10 over his last two starts. Look for the Brewers to continue their strong home play and secure a win to close the series.
Milwaukee ML
Total Prediction For The Cardinals vs Brewers
- Under 9
While both of these teams hit well in game one, both of these pitchers have been strong on the mound this season, and they've both done a solid job when it comes to limiting home runs and walks. St. Louis has been hitting weaker on the road this season, and with their high strikeout rate, we should expect them to be slow out of the gate here. The play is the under.
Under 9
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