St. Louis Cardinals vs. Seattle Mariners Picks and Prediction, Wednesday, September 10, 2025
On Wednesday night, the St. Louis Cardinals and Seattle Mariners meet in the final game of a three-game series at T-Mobile Park, and we will set you up with a Cardinals vs. Mariners prediction to go along with free picks and a look at the game. Michael McGreevy will start for the Cardinals while Logan Gilbert pitches for the Mariners. Read on for a prediction on the score and a game breakdown. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
McGreevy Takes the Hill
Michael McGreevy will take the mound in the final game of this road series. He took the loss Friday against the Giants, allowing six runs on nine hits and one walk in four innings. He struck out three in the contest.
- He served up back-to-back homers to Rafael Devers and Willy Adames in the opening frame, then kept the Giants off the board until they erupted for four more in the fourth inning.
- According to Yahoo.com, the 25-year-old hurler got six swings and misses on 75 pitches on the night, registering a CSW of 27 percent.
- McGreevy was tormented during his shortest start of the year, tying a season high in hits allowed. The six runs given up were one shy of his season worst, and he pitched fewer than five innings for only the third time in 13 outings on the campaign.
- The right-hander owns an uninspiring 4.68 ERA, 1.26 WHIP, and 43:12 K:BB in 2025.
St. Louis remains 4.5 games behind the third and final wild card spot. They have a -42 run differential leading into action Tuesday in what has been a disappointing season.
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Gilbert Will Pitch the Finale
The Mariners will send Logan Gilbert to the hill for the final game of this interleague series with the Cardinals. Gilbert did not factor into the decision against Atlanta on Friday, allowing one run on five hits and one walk while striking out seven over six innings.
- Gilbert did not factor into the decision against Atlanta on Friday, allowing one run on five hits and one walk while striking out seven over six innings.
- The right-hander looked shaky out of the gate, loading the bases with the first three batters he faced, but he limited the damage to a single run, punching out Michael Harris with two men on base. The 28-year-old right-hander has allowed just one run in two of his last three starts.
- Gilbert settled in after the first, retiring 15 of the next 18 hitters he faced to post his third consecutive quality start. Over that stretch, the 28-year-old has logged a 2.50 ERA and 26 strikeouts across 18 innings, though he's come away with just one win. Gilbert will look to keep rolling in this next scheduled start against St. Louis.
Seattle has a 1.5-game lead on the third and final wild-card spot.
Cardinals vs. Mariners Game Pick
- Seattle Mariners -1.5 (4 units)
In what has been a desperate race to the finish in the American League, Seattle is fighting for their playoff lives. They are clinging to a 1.5-game lead on the third and final wild card. They have their most consistent pitcher on the mound for this home game against the Cardinals, and I expect Gibert to deliver another strong performance. The 28-year-old right-hander has allowed just one run in two of his last three starts, all quality starts. Over that stretch, the 28-year-old has logged a 2.50 ERA and 26 strikeouts across 18 innings. Take the Mariners to win by two or more.
- OVER (5 units)
Michael McGreevy will take the mound in the final game of this road series. He took the loss Friday against the Giants, allowing six runs on nine hits and one walk in four innings. The right-hander owns an uninspiring 4.68 ERA, 1.26 WHIP, and 43:12 K:BB. Over their last 10 games against the Mariners, the St. Louis offense has been unproductive, scoring an average of 3.60 runs. Seattle has been a dominant home club lately, winning 12 of their last 14 games at T Mobile. Take the over here.
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