Philadelphia vs Cleveland Prediction, Picks & Odds (Nov 5, 2025): Best Bets for Spread and Total

Philadelphia vs Cleveland Prediction, Picks & NBA Betting Preview – November 5, 2025

The Cleveland Cavaliers host the Philadelphia 76ers in an Eastern Conference matchup on Wednesday night. According to the latest projection, Cleveland is favored by 10 points with a game total of 235.5.

This matchup features two teams moving in opposite directions. Philadelphia has covered the spread in five of the last six meetings, but Cleveland’s recent surge in defense has shifted the tone of this rivalry heading into tonight’s contest.

Philadelphia vs Cleveland Betting Odds & Data

• Predicted Score: Cleveland 119 – Philadelphia 111
• Line: Cleveland -10
• Total: 235.5
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• Power Ratings: Philadelphia 7.5 | Cleveland 6.5 (GS Line: CLE -4)
• ATS (H/A): Philadelphia 2-1 / 3-0 | Cleveland 1-2 / 1-3
• O/U (H/A): Philadelphia 2-1 / 3-1 | Cleveland 0-3 / 2-2
• Points Diff (H/A): Philadelphia +5 / +7 | Cleveland +0.7 / 0

Philadelphia 76ers Analysis

Philadelphia has covered in five of the last six meetings between these teams, but they enter tonight’s game on the second leg of a back-to-back after losing in Chicago. The Sixers’ offense remains capable, yet the fatigue factor could limit their pace. They are still one of the NBA’s stronger defensive rebounding teams but have struggled when facing physical frontcourts like Cleveland’s.

Cleveland Cavaliers Analysis

Cleveland has tightened up defensively, with all five of its most recent games staying under the total. The Cavaliers are well-rested and playing with improved intensity, especially at home. Darius Garland is expected to play, while Sam Merrill and Jarrett Allen remain questionable. Even with those potential absences, Cleveland has turned a corner on the defensive end — ranking in the bottom five in effective field goal percentage earlier in the year but improving significantly over the last two weeks.

Matchup Breakdown

Last season, three of the four meetings between these teams went over the total, but this year’s version of the Cavaliers has slowed games down. Cleveland’s defense is allowing fewer easy looks, while Philadelphia has struggled to create consistent offense in half-court sets, especially on tired legs.

Philadelphia’s road form is concerning here, while Cleveland’s depth and rest advantage should carry the night. The projected scoring margin also aligns with the Cavaliers -10 spread, suggesting a home cover in a lower-than-expected scoring game.

Philadelphia vs Cleveland Prediction

Pick: Cleveland -10 ★★ (2-Star Confidence)

Cleveland’s defensive consistency and rest advantage make them the sharper side. Philadelphia’s short turnaround and travel spot are tough to overcome. Expect the Cavaliers to pull away late behind improved shooting efficiency and rebounding dominance.

Total: Under 235.5 ★★★ (3-Star Confidence)

Five of Cleveland’s last five games have stayed under, and the Sixers’ offense may struggle to keep pace. With both teams leaning on defense and slower possessions, this total feels inflated. The projected 230 combined points fall below the posted number.

Projected Score

Cleveland 119 – Philadelphia 105

Best Bets Summary

Bet Type	Selection	Confidence	Reasoning
Spread	Cleveland -10	★★	Rest advantage and defensive momentum favor Cavaliers at home
Total	Under 235.5	★★★	Five straight Cavs unders; Philadelphia’s second game in two nights limits pace

Final Thoughts

This Philadelphia vs Cleveland prediction leans to the home side in a controlled, defensive contest. Cleveland’s improved form and rest advantage should prove decisive. Look for a Cavs cover and the under to continue cashing in Cavaliers games.