LSU vs Alabama Picks, Predictions, Odds, and Trends for Saturday

Alabama has won and covered the spread in each of the last two meetings with LSU, including a commanding 42–13 road win in Baton Rouge last season.

Both teams enter Week 11 coming off a bye, which could not have arrived at a better time. Check out Alabama vs LSU picks using matchup insights from WagerTalk where we also cover other college football picks for Week 11!

Quick Picks and Prediction on LSU vs Alabama

if you are in a hurry, here is a quick guide to what you’re looking for

Alabama has won and covered the spread in the last two meetings.
The Crimson Tide defeated LSU 42–13 on the road last season.
A strong LSU performance would signal the start of a new era post-Kelly.
Alabama looks to continue its dominant form and maintain SEC title momentum.

LSU vs Alabama Odds and Line Movement

Check out LSU vs Alabama Odds including where the opening lines were vs what they are now as well as totals!

Game Time	7:30PM ET / 4:30 PM PT
Opening Line Total / Current Spread Total	Alabama -10.5 50.5 / Alabama -10.5 49.5
Location	Bryant-Denny Stadium in Tuscaloosa, AL
TV	ABC

Key Matchups for LSU vs Alabama

LSU Offensive Line vs Alabama Pass Rush

Protecting the quarterback is critical for LSU in this matchup.
Alabama’s defensive front, which caused trouble for Missouri and South Carolina during that five-game run, will challenge LSU’s ability to sustain drives.

LSU Wide Receivers vs Alabama Secondary

With a new system and coaching energy post-Kelly, LSU’s receivers could be rejuvenated and motivated.
Alabama’s secondary has been consistently tested by ranked teams and is unlikely to give up easy deep shots.
This matchup will determine if LSU can produce explosive plays or be forced into short, methodical drives.

Alabama Quarterback vs LSU Linebackers and Secondary

Alabama’s offense remains efficient but has faced fatigue after multiple high-intensity matchups.
LSU’s defense enters this game with emotional momentum and the desire to “bury the Kelly regime.”

Betting Trends for Alabama vs LSU

Alabama Dominance Against the Spread (ATS):

“Alabama has won and covered the last two meetings, including a 42–13 road win at LSU last year.”
✅ Trend Insight: The Crimson Tide have both won outright and covered the spread in consecutive gamesversus LSU, signaling consistent performance relative to betting expectations in this series.

Power Ratings Support Alabama as a Strong Favorite:

“Our power ratings still believe that Alabama is a worthy double-digit favorite.”
✅ Trend Insight: Analytical models continue to rate Alabama as a double-digit favorite, suggesting sustained market confidence in their superiority over LSU despite potential motivational factors for the Tigers.

Alabama vs LSU ATS and Over/Under Betting Picks

Overall this looks to be another fantastic game between Alabama and LSU! Let’s look at the free ATS and total pick below!

LSU vs Alabama Spread

LSU +9.5

LSU vs Alabama Final Score Prediction

27-24 Alabama

Alabama remains the statistical and betting favorite, but LSU could keep it close if morale and energy are high. Expect a potential one-score game in the fourth quarter if LSU channels the emotional momentum.

How To Bet on Alabama vs LSU

You can bet on LSU vs Alabama through any licensed sportsbook offering college football odds, including online platforms such as FanDuel, DraftKings, BetMGM, or Caesars Sportsbook, as well as legal retail locations in states that permit sports wagering.

Bettors can wager on the point spread, moneyline, or total (over/under) for the Week 11 matchup. Always check for updated odds and responsible gambling guidelines before placing bets.

Odds and lines can shift throughout the week, especially following injury updates or coaching changes.

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WagerTalk Live Odds Screen

WagerTalk’s live odds screen features up-to-the-minute lines from a variety of offshore and domestic sports books. Track the moneylines, point spreads, totals and betting percentages for all of the college football Week 11 games, including Mountain West college football contests. Find free college football picks from season win total bets through National Championship futures on our free picks pages.

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